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M. Maguire-Eisen (2013)
Skin cancer: a growing health problem for children.Seminars in oncology nursing, 29 3
M. Urist, C. Balch, S. Soong, H. Shaw, G. Milton, W. Maddox (1985)
The influence of surgical margins and prognostic factors predicting the risk of local recurrence in 3445 patients with primary cutaneous melanomaCancer, 55
D. Davar, A. Tarhini, J. Kirkwood (2012)
Adjuvant Therapy for MelanomaThe Cancer Journal, 18
K. Markou, A. Nikolaou, C. Themelis (2011)
National Comprehensive Cancer Network (NCCN) Head and Neck Cancers NCCN Clinical Practice Guidelines in Oncology . 2010.
H. Drepper, B. Bastian, H. Breuninger, Ej Eva-B, J. Göhl, W. Groth, P. Hermanek, B. Hohenberger, A. Lippold, Kölmel Kf, M. Landthaler, W. Tilgen (1993)
Benefit of Elective Lymph Node Dissection in Subgroups of Melanoma Patients
Y. Xing, B. Badgwell, M. Ross, J. Gershenwald, Jeffrey Lee, P. Mansfield, A. Lucci, J. Cormier (2009)
Lymph node ratio predicts disease‐specific survival in melanoma patientsCancer, 115
A. Erman, Ryan Collar, K. Griffith, L. Lowe, M. Sabel, C. Bichakjian, S. Wong, S. Mclean, R. Rees, T. Johnson, C. Bradford (2012)
Sentinel lymph node biopsy is accurate and prognostic in head and neck melanomaCancer, 118
D. Morton, J. Thompson, A. Cochran, N. Mozzillo, R. Elashoff, R. Essner, O. Nieweg, D. Roses, H. Hoekstra, C. Karakousis, D. Reintgen, B. Coventry, E. Glass, He-jing Wang (2006)
Sentinel-node biopsy or nodal observation in melanoma.The New England journal of medicine, 355 13
C. Balch, S. Soong, A. Bartolucci, M. Urist, C. Karakousis, T. Smith, W. Temple, M. Ross, W. Jewell, M. Mihm, R. Barnhill, H. Wanebo (1996)
Efficacy of an elective regional lymph node dissection of 1 to 4 mm thick melanomas for patients 60 years of age and younger.Annals of surgery, 224 3
P. Lang (2007)
Sentinel-Node Biopsy or Nodal Observation in MelanomaYearbook of Dermatology and Dermatologic Surgery, 2007
Willem Vrie, A. Eggermont, W. Putten, T. Wiggers (1993)
Therapeutic lymphadenectomy in melanomas of the head and neckHead & Neck, 15
CM Balch, SJ Soong, JE Gershenwald (2001)
Prognostic factors analysis of 17,600 melanoma patients: validation of the AJCC melanoma staging system., 19
C. O'brien, K. Petersen‐Schaefer, D. Ruark, A. Coates, S. Menzie, R. Harrison (1995)
Radical, modified, and selective neck dissection for cutaneous malignant melanomaHead & Neck, 17
H. Drepper, C. Köhler, B. Bastian, H. Breuninger, E. Bröcker, J. Göhl, W. Groth, P. Hermanek, W. Hohenberger, A. Lippold, K. Kölmel, M. Landthaler, A. Peters, W. Tilgen (1993)
Benefit of elective lymph node dissection in subgroups of melanoma patients. Results of a multicenter study of 3616 patientsCancer, 72
A. Jonk, L. Strobbe, B. Kroon, W. Mooi, A. Hart, O. Nieweg, A. Balm (1998)
Cervical lymph-node metastasis from cutaneous melanoma of the head and neck: a search for prognostic factors.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 24 4
F. Sim, W. Taylor, J. Ivins, D. Pritchard, E. Soule (1978)
A prospective randomized study of the efficacy of routine elective lymphadenectomy in management of malignant melanoma. Preliminary resultsCancer, 41
S. Fisher (2002)
Elective, Therapeutic, and Delayed Lymph Node Dissection for Malignant Melanoma of the Head and Neck: Analysis of 1444 Patients From 1970 to 1998The Laryngoscope, 112
C. Balch, S. Soong, J. Gershenwald, J. Thompson, D. Reintgen, N. Cascinelli, M. Urist, K. McMasters, M. Ross, J. Kirkwood, M. Atkins, John Thompson, D. Coit, D. Byrd, Renee Desmond, Yuting Zhang, Ping-Yu Liu, G. Lyman, A. Morabito (2001)
Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 19 16
L. Turkula, John Woods (1984)
Limited or selective nodal dissection for malignant melanoma of the head and neck.American journal of surgery, 148 4
L. Mack, J. Mckinnon (2004)
Controversies in the management of metastatic melanoma to regional lymphatic basinsJournal of Surgical Oncology, 86
S. Leong (2011)
Role of selective sentinel lymph node dissection in head and neck melanomaJournal of Surgical Oncology, 104
Umberto Veronesi, J. Adamus, D. Bandiera, I. Brennhovd, E. Cáceres, N. Cascinelli, F. Claudio, R. Ikonopisov, V. Javorski, S. Kirov, A. Kułakowski, J. Lacour, F. Lejeune, Z. Mechl, A. Morabito, I. Rodé, S. Sergeev, E. Slooten, K. Szczygieł, N. Trapeznikov, R. Wagner (1982)
Delayed regional lymph node dissection in stage I melanoma of the skin of the lower extremitiesCancer, 49
ImportanceHistorically, patients with cervical metastases from melanoma of the head and neck were treated with a radical neck dissection. This study evaluates the efficacy of limiting the extent of lymphadenectomy in this high-risk population. ObjectivesTo determine whether limiting the extent of lymphadenectomy for patients with biopsy-proven melanoma has a negative effect on regional control. Our hypothesis was that performing a more limited lymphadenectomy does not have a negative impact on regional control. Design, Setting, and ParticipantsA retrospective, single-cohort study was performed using a prospectively collected database of patients with head and neck melanoma with histopathologically positive lymph nodes after modified radical (MRND) or selective neck dissection (SNDs) performed at a high-volume, academic, tertiary care center. InterventionsLymphadenectomy was performed as clinically indicated. Main Outcomes and MeasuresPrimary end points were regional recurrence and regional recurrence free survival. Univariable and multivariable analyses were conducted using multiple patient characteristics. ResultsForty-one patients underwent SND or MRND from 2001 through 2010. The median number of positive nodes was 1 (range, 1-16). Twenty-six patients (63%) received adjuvant radiation and 23 patients (56%) received adjuvant immunotherapy or chemotherapy. The median follow-up time was 17 months (range, 1-116 months). Regional control was achieved in 29 patients (71%). Median regional recurrence-free survival was 21 months (range, 1-116 months). Age (hazard ratio [HR], 1.13; 95% CI, 1.01-1.26), total number of nodes examined (HR, 1.05; 95% CI, 1.01-1.10), and number of sentinel lymph nodes examined (HR, 1.45; 95% CI, 1.01-2.09) were all significantly associated with increased recurrence-free survival. Tumor depth, extracapsular spread, number of nodes positive, prior SLNB, extent of lymphadenectomy, and adjuvant therapy were not significant. Conclusions and RelevanceLimiting the extent of lymphadenectomy with frequent use of adjuvant radiation therapy is effective in achieving regional control of head and neck melanoma with cervical metastases.
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Nov 1, 2014
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