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Estimated Utility of the Short-term Assessment of Glaucoma Progression Model in Clinical Practice

Estimated Utility of the Short-term Assessment of Glaucoma Progression Model in Clinical Practice Key PointsQuestionCan a study design that evaluates current clinical practice assess glaucomatous change in a shorter than usual study period in patients with glaucoma? FindingsIn this cohort study of 178 eyes from 97 patients with glaucoma, with testing every 3 months, clinically relevant rates of retinal nerve fiber layer and visual field mean deviation change were detected in 18 months. Assuming moderate differences in the rates of change and testing every 3 months, sufficient power was demonstrated for glaucoma therapy trials with 18 months follow-up. MeaningIn this study using frequent testing and the rate of change in retinal nerve fiber layer thickness or visual field mean deviation as the end point, the results suggest that clinical trials of glaucoma therapy can be completed within a relatively short time frame. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

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References (86)

Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/jamaophthalmol.2021.1812
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionCan a study design that evaluates current clinical practice assess glaucomatous change in a shorter than usual study period in patients with glaucoma? FindingsIn this cohort study of 178 eyes from 97 patients with glaucoma, with testing every 3 months, clinically relevant rates of retinal nerve fiber layer and visual field mean deviation change were detected in 18 months. Assuming moderate differences in the rates of change and testing every 3 months, sufficient power was demonstrated for glaucoma therapy trials with 18 months follow-up. MeaningIn this study using frequent testing and the rate of change in retinal nerve fiber layer thickness or visual field mean deviation as the end point, the results suggest that clinical trials of glaucoma therapy can be completed within a relatively short time frame.

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Aug 10, 2021

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