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Key PointsQuestionCan a study design that evaluates current clinical practice assess glaucomatous change in a shorter than usual study period in patients with glaucoma? FindingsIn this cohort study of 178 eyes from 97 patients with glaucoma, with testing every 3 months, clinically relevant rates of retinal nerve fiber layer and visual field mean deviation change were detected in 18 months. Assuming moderate differences in the rates of change and testing every 3 months, sufficient power was demonstrated for glaucoma therapy trials with 18 months follow-up. MeaningIn this study using frequent testing and the rate of change in retinal nerve fiber layer thickness or visual field mean deviation as the end point, the results suggest that clinical trials of glaucoma therapy can be completed within a relatively short time frame.
JAMA Ophthalmology – American Medical Association
Published: Aug 10, 2021
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