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Key PointsQuestionWhich biomarkers calculated from ultrawidefield fluorescein images of patients with diabetes are most associated with demographic risk factors and retinopathy progression? FindingsIn this case series, male sex, black race/ethnicity, and presence of vitreous hemorrhage were most strongly associated with greater areas of nonperfusion and neovascularization, and a retinal nonperfusion threshold of 77.48 mm2 may be associated with increased risk for progression. Given the study’s design, statistical significance could not be established. MeaningThese results suggest which factors may indicate higher risk of severe disease progression, and eyes with at least 77.48 mm2 nonperfusion are at risk of proliferative retinopathy.
JAMA Ophthalmology – American Medical Association
Published: Jun 30, 2020
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