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Quantification of Retinal Nonperfusion and Neovascularization With Ultrawidefield Fluorescein Angiography in Patients With Diabetes and Associated Characteristics of Advanced Disease

Quantification of Retinal Nonperfusion and Neovascularization With Ultrawidefield Fluorescein... Key PointsQuestionWhich biomarkers calculated from ultrawidefield fluorescein images of patients with diabetes are most associated with demographic risk factors and retinopathy progression? FindingsIn this case series, male sex, black race/ethnicity, and presence of vitreous hemorrhage were most strongly associated with greater areas of nonperfusion and neovascularization, and a retinal nonperfusion threshold of 77.48 mm2 may be associated with increased risk for progression. Given the study’s design, statistical significance could not be established. MeaningThese results suggest which factors may indicate higher risk of severe disease progression, and eyes with at least 77.48 mm2 nonperfusion are at risk of proliferative retinopathy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Quantification of Retinal Nonperfusion and Neovascularization With Ultrawidefield Fluorescein Angiography in Patients With Diabetes and Associated Characteristics of Advanced Disease

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References (41)

Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/jamaophthalmol.2020.1257
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhich biomarkers calculated from ultrawidefield fluorescein images of patients with diabetes are most associated with demographic risk factors and retinopathy progression? FindingsIn this case series, male sex, black race/ethnicity, and presence of vitreous hemorrhage were most strongly associated with greater areas of nonperfusion and neovascularization, and a retinal nonperfusion threshold of 77.48 mm2 may be associated with increased risk for progression. Given the study’s design, statistical significance could not be established. MeaningThese results suggest which factors may indicate higher risk of severe disease progression, and eyes with at least 77.48 mm2 nonperfusion are at risk of proliferative retinopathy.

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Jun 30, 2020

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