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Age-Related Maculopathy—Degeneration by Generation

Age-Related Maculopathy—Degeneration by Generation Research Original Investigation Generational Differences in the 5-Year Incidence of Age-Related Macular Degeneration Invited Commentary Raphael R. Goldacre, MSc; Tiarnan D. L. Keenan, PhD We are used to hearing that the burden of age-related macu- If we assume that the incidence and prevalence of AMD lar degeneration (AMD) in developed countries is increasing have been decreasing over time, it is interesting to speculate because of increased life expectancies and aging popula- on potential reasons why this has occurred. Genetic change be- tions. However, it is also important to consider whether age- tween generations and population fluxes are unlikely to be re- adjusted rates of AMD are sponsible, leaving environmental factors as potential factors. changing and, if so, in which The advent and uptake of high-dose antioxidant/vitamin/ zinc supplementation (which decreases progression from in- Related article page 1417 direction. Aside from help- ing predict future require- termediate to late AMD ) could partially explain a lower preva- ments for ophthalmic services, age-specific trends might pro- lence of late AMD; however, in this case, a corresponding vide important insights into AMD pathophysiology, particularly increase in the prevalence of intermediate AMD might be ex- on the role of various environmental risk factors http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Age-Related Maculopathy—Degeneration by Generation

JAMA Ophthalmology , Volume 135 (12) – Dec 16, 2017

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References (7)

Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/jamaophthalmol.2017.5052
Publisher site
See Article on Publisher Site

Abstract

Research Original Investigation Generational Differences in the 5-Year Incidence of Age-Related Macular Degeneration Invited Commentary Raphael R. Goldacre, MSc; Tiarnan D. L. Keenan, PhD We are used to hearing that the burden of age-related macu- If we assume that the incidence and prevalence of AMD lar degeneration (AMD) in developed countries is increasing have been decreasing over time, it is interesting to speculate because of increased life expectancies and aging popula- on potential reasons why this has occurred. Genetic change be- tions. However, it is also important to consider whether age- tween generations and population fluxes are unlikely to be re- adjusted rates of AMD are sponsible, leaving environmental factors as potential factors. changing and, if so, in which The advent and uptake of high-dose antioxidant/vitamin/ zinc supplementation (which decreases progression from in- Related article page 1417 direction. Aside from help- ing predict future require- termediate to late AMD ) could partially explain a lower preva- ments for ophthalmic services, age-specific trends might pro- lence of late AMD; however, in this case, a corresponding vide important insights into AMD pathophysiology, particularly increase in the prevalence of intermediate AMD might be ex- on the role of various environmental risk factors

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Dec 16, 2017

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