Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Rubin, L. Robison, J. Cameron, W. Woods, M. Nesbit, W. Krivit, T. Kim, R. Letson, N. Ramsay (1985)
Intraocular retinoblastoma group V: an analysis of prognostic factors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 3 5
Nathália Grigorovski, E. Lucena, C. Mattosinho, A. Parareda, S. Ferman, J. Català, G. Chantada (2014)
Use of intra-arterial chemotherapy for retinoblastoma: results of a survey.International journal of ophthalmology, 7 4
A. Singh, C. Shields, J. Shields (2000)
Prognostic factors in retinoblastoma.Journal of pediatric ophthalmology and strabismus, 37 3
F. Doz, F. Khelfaoui, V. Mosseri, P. Validire, E. Quintana, J. Michon, L. Desjardins, P. Schlienger, S. Neuenschwander, P. Vielh, M. Putterman, J. Dufier, J. Zucker (1994)
The role of chemotherapy in orbital involvement of retinoblastoma. The experience of a single institution with 33 patientsCancer, 74
E. Peterson, M. Elhammady, S. Quintero-Wolfe, T. Murray, M. Aziz-Sultan (2011)
Selective ophthalmic artery infusion of chemotherapy for advanced intraocular retinoblastoma: initial experience with 17 tumors.Journal of neurosurgery, 114 6
G. Chantada, A. González, A. Fandiño, M. Dávila, G. Demirdjian, M. Scopinaro, D. Abramson (2009)
Some Clinical Findings at Presentation Can Predict High-risk Pathology Features in Unilateral RetinoblastomaJournal of Pediatric Hematology/Oncology, 31
C. Shields, Fairooz Manjandavida, S. Lally, Giulia Pieretti, Sruthi Arepalli, Emi Caywood, P. Jabbour, J. Shields (2014)
Intra-arterial chemotherapy for retinoblastoma in 70 eyes: outcomes based on the international classification of retinoblastoma.Ophthalmology, 121 7
Jonathan Kim, Vinnie Kathpalia, I. Dunkel, Ryan Wong, Elyn Riedel, David Abramson (2008)
Orbital recurrence of retinoblastoma following enucleationBritish Journal of Ophthalmology, 93
J. Hungerford, J. Kingston, N. Plowman (1987)
Orbital recurrence of retinoblastoma.Ophthalmic paediatrics and genetics, 8 1
P. Jabbour, N. Chalouhi, S. Tjoumakaris, L. Gonzalez, A. Dumont, R. Chitale, R. Rosenwasser, C. Bianciotto, C. Shields (2012)
Pearls and pitfalls of intraarterial chemotherapy for retinoblastoma.Journal of neurosurgery. Pediatrics, 10 3
Y. Gobin, I. Dunkel, B. Marr, S. Brodie, D. Abramson (2011)
Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience.Archives of ophthalmology, 129 6
Y. Gobin, I. Dunkel, B. Marr, J. Francis, S. Brodie, D. Abramson (2012)
Combined, Sequential Intravenous and Intra-Arterial Chemotherapy (Bridge Chemotherapy) for Young Infants with RetinoblastomaPLoS ONE, 7
D. Abramson, J. Francis, I. Dunkel, B. Marr, S. Brodie, Y. Gobin (2013)
Ophthalmic artery chemosurgery for retinoblastoma prevents new intraocular tumors.Ophthalmology, 120 3
R. Ellsworth (1974)
Orbital retinoblastoma.Transactions of the American Ophthalmological Society, 72
F. Khelfaoui, P. Validire, A. Aupérin, E. Quintana, J. Michon, H. Pacquement, L. Desjardins, B. Asselain, P. Schlienger, P. Vielh, J. Dufier, J. Zucker, F. Doz (1996)
Histopathologic risk factors in retinoblastoma: A retrospective study of 172 patients treated in a single institutionCancer, 77
D. Abramson, B. Marr, I. Dunkel, S. Brodie, E. Zabor, S. Driscoll, P. Gobin (2011)
Intra-arterial chemotherapy for retinoblastoma in eyes with vitreous and/or subretinal seeding: 2-year resultsBritish Journal of Ophthalmology, 96
K. Baez, M. Ulbig, J. Cater, C. Shields, J. Shields (1994)
[Iris neovascularization, increased intraocular pressure and vitreous hemorrhage as risk factors for invasion of the optic nerve and choroid in children with retinoblastoma].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 91 6
J. Kopelman, I. McLean, S. Rosenberg (1987)
Multivariate analysis of risk factors for metastasis in retinoblastoma treated by enucleation.Ophthalmology, 94 4
C. Shields, J. Shields, K. Baez, J. Cater, P. Potter (1993)
Choroidal invasion of retinoblastoma: metastatic potential and clinical risk factors.British Journal of Ophthalmology, 77
Shigenobu Suzuki, T. Yamane, M. Mohri, A. Kaneko (2011)
Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis.Ophthalmology, 118 10
C. Shields, J. Shields (2010)
Intra‐arterial chemotherapy for retinoblastoma: the beginning of a long journeyClinical & Experimental Ophthalmology, 38
ImportanceOphthalmic artery chemosurgery (OAC) has emerged as a primary treatment for advanced-stage retinoblastoma. To our knowledge, the incidence of orbital recurrence in eyes treated with OAC has not been described. ObjectiveTo determine the incidence of orbital recurrence following enucleation or OAC as primary treatments for advanced-stage retinoblastoma. Design, Setting, and ParticipantsSingle-institution cohort study with retrospective record review at an academic ophthalmic oncology practice. A total of 140 eyes in 135 patients who presented between February 14, 2006, and March 4, 2014, and were classified as having Reese-Ellsworth group 5 or International Classification of Retinoblastoma (Children’s Oncology Group) group D or E retinoblastoma were included; 63 patients (63 eyes) were primarily treated with enucleation and 72 patients (77 eyes) were primarily treated with OAC. This analysis was conducted between August 1, 2014, and March 1, 2015. Main Outcomes and MeasuresIncidence of and time to orbital recurrence, metastasis, and death. ResultsThere were 5 orbital recurrences (incidence, 7.9%) in the primary enucleation group and 1 orbital recurrence (incidence, 1.3%) in the primary OAC group during median follow-up times of 42.6 months (range, 6.2-97.1 months) and 38.7 months (range, 9.0-104.3 months), respectively. The 24-month Kaplan-Meier estimate for orbital recurrence–free survival was worse for the enucleation group (92.1%; 95% CI, 82.0-96.7) than for the OAC group (100%) (log-rank test, P = .049). The enucleation group had 5 cases of metastatic disease (7.9%) and 2 deaths (3.2%). In the OAC group, there were 3 cases of metastatic disease (4.2%) and no deaths. Kaplan-Meier analysis of metastasis-free survival and overall survival yielded no differences between the 2 treatment groups. Analysis of a number of features of the 2 groups revealed more eyes with iris neovascularization in the enucleation group (25.4%) than in the OAC group (5.2%) and more eyes with group E retinoblastoma in the enucleation group (87.3%) than in the OAC group (29.9%), although neither of these factors was an independent predictor of orbital relapse in a Cox proportional hazards model. Conclusions and RelevanceIn this single-institution retrospective study of advanced intraocular retinoblastoma, there were more orbital recurrences in the group primarily treated with enucleation. Ophthalmic artery chemosurgery for advanced intraocular retinoblastoma was not found to increase the chance of orbital recurrence, metastatic disease, or death compared with primary enucleation.
JAMA Ophthalmology – American Medical Association
Published: Sep 1, 2015
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.