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Opinion EDITORIAL Ocriplasmin, Ocriplasmin; Oh, How Safe Art Thou? Judy E. Kim, MD Our ability to examine the vitreoretinal interface has been However, since the real-world use of the drug began, there greatly improved by the invention of spectral-domain optical have been unfavorable anecdotal reports of visual distur- coherence tomography (OCT). It has allowed earlier and more bances after ocriplasmin injection, including transient but pro- accurate diagnosis of abnormalities of vitreomacular adhe- found visual decline, raising concerns regarding its safety. sion (VMA) that may contribute to vision loss and may ben- While it is not possible to know the frequency of these events efit from intervention. While subtle abnormalities of VMA may in postmarketing surveillance, it is worthwhile to pay atten- be observed, symptomatic VMA or that associated with full- tion to safety-related reports. thickness macular hole (FTMH) requires surgical intervention. In the report of phase 3 trials of ocriplasmin, ocular ad- With improvements in vitreoretinal surgical techniques and verse events such as vitreous floaters, photopsia, conjuncti- better understanding of these conditions, outcomes of surgi- val hemorrhage, blurred vision, and visual impairment were cal management of VMA-related disorders are excellent. How- found to be significantly higher in the treatment
JAMA Ophthalmology – American Medical Association
Published: Apr 1, 2014
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