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Letters Figure 2. Influence of Azithromycin on Proliferation of Immortalized Human Meibomian Gland Epithelial Cells A B Baseline Control Azithromycin 250 000 250 000 200 000 200 000 150 000 150 000 100 000 a 100 000 Cells were cultured in the absence (A) a or presence (B) of serum for up to 7 50 000 50 000 days. Cell numbers at day 0 represent the baseline, and data are reported as 0 0 mean ± standard error. Similar results 0 1 3 5 7 0 1 3 5 7 were found in 2 additional studies. Day Day Significantly less than control (P < .005). and is associated with significant pain, role limitations, low 3. Geerling G, Tauber J, Baudouin C, et al. The international workshop on meibomian gland dysfunction: report of the subcommittee on management vitality, and poor general health. and treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci. Given our finding that azithromycin stimulates the func- 2011;52(4):2050-2064. tion and differentiation of IHMGECs in vitro, it is possible that 4. Liu S, Kam WR, Ding J, Hatton MP, Sullivan DA. Effect of growth factors on this antibiotic may prove beneficial as a treatment for MGD and the
JAMA Ophthalmology – American Medical Association
Published: Feb 1, 2014
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