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- Publisher
- American Medical Association
- Copyright
- Copyright 2018 American Medical Association. All Rights Reserved.
- ISSN
- 2374-2437
- eISSN
- 2374-2445
- DOI
- 10.1001/jamaoncol.2018.5625
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionWhat is the association of therapy-related myelodysplastic syndrome or acute myeloid leukemia (tMDS/AML) with chemotherapy for solid cancer in the modern treatment era? FindingsIn this population-based study of 700 612 adults in a US cancer data registry, based on 1619 tMDS/AML cases, the risk of tMDS/AML was significantly increased 1.5-fold to more than 10-fold after chemotherapy for 22 of 23 solid cancer types investigated (all except colon cancer). MeaningAlthough tMDS/AML is rare, gains in solid cancer survival from modern treatment approaches should be balanced against tMDS/AML risks and other chemotherapy-related adverse effects; continued efforts to develop effective agents and cancer treatment approaches with fewer late sequelae are needed.
Journal
JAMA Oncology – American Medical Association
Published: Mar 20, 2019