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Preoperative vs Postoperative CEA and Colon Cancer Outcome Original Investigation Research 27. Primrose JN, Perera R, Gray A, et al; FACS Trial survival after complete mesocolic excision with a history of resected colorectal cancer. J Natl Investigators. Effect of 3 to 5 years of scheduled compared with conventional colon cancer surgery: Compr Canc Netw. 2014;12(6):907-913. CEA and CT follow-up to detect recurrence of a retrospective, population-based study. Lancet colorectal cancer. JAMA. 2014;311(3):263-270. Oncol. 2015;16(2):161-168. 28. Bertelsen CA, Neuenschwander AU, Jansen JE, 29. Litvak A, Cercek A, Segal N, et al. False-positive et al; Danish Colorectal Cancer Group. Disease-free elevations of carcinoembryonic antigen in patients Invited Commentary Carcinoembryonic Antigen—Still More to Learn From the Real World Rebecca Anne Miksad, MD, MPH; Neal J. Meropol, MD Carcinoembryonic antigen (CEA) is a group of oncofetal gly- experienced earlier recurrence than patients who had nor- coprotein antigens involved in cell adhesion that was first de- mal baseline or postoperative CEA level. scribed in 1965. Measurement of CEA has long been recom- This study highlights the potential of real-world evidence mended as a blood-based prognostic indicator in colorectal to contribute insights that might ultimately lead to changes cancer and as a surveillance in clinical
JAMA Oncology – American Medical Association
Published: Mar 21, 2018
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