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Letters Corresponding Author: Young E. Whang, MD, PhD, Lineberger Comprehensive COMMENT & RESPONSE Cancer Center, University of North Carolina School of Medicine, 450 West Dr, Genomic Profiling of Cancers of Unknown Chapel Hill, NC 27599-7295 (ywhang@med.unc.edu). Primary Site: The Next Steps Published Online: May 14, 2015. doi:10.1001/jamaoncol.2015.0936. To the Editor A recent article by Ross et al reported the results Conflict of Interest Disclosures: None reported. of comprehensive genomic profiling of cancers of unknown pri- 1. Ross JS, Wang K, Gay L, et al. Comprehensive genomic profiling of carcinoma mary (CUPs) and documents frequent occurrence of clini- of unknown primary site: new routes to targeted therapies [published online February 12, 2015]. JAMA Oncol. doi:10.1001/jamaoncol.2014.216. cally relevant genomic alterations. We describe herein the out- 2. Kodaira M, Takahashi S, Yamada S, et al. Bone metastasis and poor come of a case of CUP, which may serve to illustrate both the performance status are prognostic factors for survival of carcinoma of unknown benefit of personalized therapy and potential pitfalls. primary site in patients treated with systematic chemotherapy. Ann Oncol. A man in his 60s presented with CUP involving bones 2010;21(6):1163-1167. and lymph nodes. He had a history of stage II testicular
JAMA Oncology – American Medical Association
Published: Jul 1, 2015
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