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G. Lu-Yao, P. Albertsen, D. Moore, W. Shih, Yong Lin, R. DiPaola, M. Barry, A. Zietman, M. O’Leary, E. Walker-Corkery, S. Yao (2009)
Outcomes of localized prostate cancer following conservative management.JAMA, 302 11
A. D'Amico, R. Whittington, S. Malkowicz, D. Schultz, K. Blank, G. Broderick, J. Tomaszewski, A. Renshaw, I. Kaplan, C. Beard, A. Wein (2000)
Biochemical Outcome After Radical Prostatectomy , External Beam Radiation Therapy , or Interstitial Radiation Therapy for Clinically Localized Prostate Cancer
Jim Hu, X. Gu, S. Lipsitz, M. Barry, A. D'Amico, A. Weinberg, N. Keating (2009)
Comparative effectiveness of minimally invasive vs open radical prostatectomy.JAMA, 302 14
J. Aragon-Ching (2011)
Reimbursement policy and androgen-deprivation therapy for prostate cancer.The New England journal of medicine, 364 6
A. Potosky, L. Harlan, J. Stanford, Frank Gilliland, A. Hamilton, P. Albertsen, J. Eley, J. Liff, D. Deapen, R. Stephenson, J. Legler, C. Ferrans, J. Talcott, M. Litwin (1999)
Prostate cancer practice patterns and quality of life: the Prostate Cancer Outcomes Study.Journal of the National Cancer Institute, 91 20
Han-Yao Huang, B. Caballero, Stephanie Chang, A. Alberg, R. Semba, C. Schneyer, Renee Wilson, Ting-Yuan Cheng, J. Vassy, G. Prokopowicz, George Barnes, E. Bass (2006)
The Efficacy and Safety of Multivitamin and Mineral Supplement Use To Prevent Cancer and Chronic Disease in Adults: A Systematic Review for a National Institutes of Health State-of-the-Science ConferenceAnnals of Internal Medicine, 145
T. Daskivich, K. Chamie, L. Kwan, Jessica Labo, R. Palvolgyi, A. Dash, S. Greenfield, M. Litwin (2011)
Overtreatment of men with low‐risk prostate cancer and significant comorbidityCancer, 117
T. Pickles, J. Ruether, L. Weir, L. Carlson, Fabijana Jakulj (2007)
Psychosocial barriers to active surveillance for the management of early prostate cancer and a strategy for increased acceptanceBJU International, 100
P. Malone (1995)
ProstateCurrent Opinion in Urology, 5
Jean Mitchell, J. Sunshine (1992)
Consequences of physicians' ownership of health care facilities--joint ventures in radiation therapy.The New England journal of medicine, 327 21
J. Warren, C. Klabunde, D. Schrag, P. Bach, G. Riley (2002)
Overview of the SEER-Medicare Data: Content, Research Applications, and Generalizability to the United States Elderly PopulationMedical Care, 40
G. Grossfeld, J. Chang, J. Broering, Y. Li, D. Lubeck, S. Flanders, P. Carroll (2001)
Under staging and under grading in a contemporary series of patients undergoing radical prostatectomy: results from the Cancer of the Prostate Strategic Urologic Research Endeavor database.The Journal of urology, 165 3
Jinping Xu, R. Dailey, S. Eggly, A. Neale, K. Schwartz (2011)
Men's perspectives on selecting their prostate cancer treatment.Journal of the National Medical Association, 103 6
D. Levin, V. Rao, L. Parker, A. Frangos, J. Sunshine (2008)
Ownership or leasing of CT scanners by nonradiologist physicians: a rapidly growing trend that raises concern about self-referral.Journal of the American College of Radiology : JACR, 5 12
R. Godtman, E. Holmberg, A. Khatami, J. Stranne, J. Hugosson (2013)
Outcome following active surveillance of men with screen-detected prostate cancer. Results from the Göteborg randomised population-based prostate cancer screening trial.European urology, 63 1
N. Dubrawsky (1989)
Cancer statisticsCA: A Cancer Journal for Clinicians, 39
R. Siegel, Jiemin Ma, Zhaohui Zou, A. Jemal (2014)
Cancer statistics, 2014CA: A Cancer Journal for Clinicians, 64
S. Loeb, A. Berglund, P. Stattin (2013)
Population based study of use and determinants of active surveillance and watchful waiting for low and intermediate risk prostate cancer.The Journal of urology, 190 5
W. Browne, S. Subramanian, K. Jones, H. Goldstein (2005)
Variance partitioning in multilevel logistic models that exhibit overdispersionJournal of the Royal Statistical Society: Series A (Statistics in Society), 168
M. Schymura, A. Kahn, R. German, M. Hsieh, R. Cress, J. Finch, J. Fulton, T. Shen, Erik Stuckart (2010)
Factors associated with initial treatment and survival for clinically localized prostate cancer: results from the CDC-NPCR Patterns of Care Study (PoC1)BMC Cancer, 10
D. Makarov, B. Trock, E. Humphreys, L. Mangold, P. Walsh, J. Epstein, A. Partin (2007)
Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000 to 2005.Urology, 69 6
A. Bill-Axelson, L. Holmberg, H. Garmo, Jennifer Rider, K. Taari, C. Busch, S. Nordling, M. Häggman, S. Andersson, A. Spångberg, O. Andrén, J. Palmgren, G. Steineck, H. Adami, J. Johansson (2014)
Radical prostatectomy or watchful waiting in early prostate cancer.The New England journal of medicine, 370 10
J. Sammon, Q. Trinh, M. Menon (2014)
Use of advanced treatment technologies among men at low risk of dying from prostate cancerBJU International, 114
P. Bach, E. Guadagnoli, D. Schrag, N. Schussler, J. Warren (2002)
Patient Demographic and Socioeconomic Characteristics in the SEER-Medicare Database: Applications and LimitationsMedical Care, 40
P. Nguyen, X. Gu, S. Lipsitz, T. Choueiri, W. Choi, Yin Lei, K. Hoffman, Jim Hu (2011)
Cost implications of the rapid adoption of newer technologies for treating prostate cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29 12
J. Bekelman, G. Suneja, T. Guzzo, C. Pollack, K. Armstrong, A. Epstein (2013)
Effect of practice integration between urologists and radiation oncologists on prostate cancer treatment patterns.The Journal of urology, 190 1
Jean Mitchell (2013)
Urologists' use of intensity-modulated radiation therapy for prostate cancer.The New England journal of medicine, 369 17
J. Hayes, D. Ollendorf, S. Pearson, M. Barry, P. Kantoff, Susan Stewart, V. Bhatnagar, C. Sweeney, J. Stahl, P. McMahon (2010)
Active surveillance compared with initial treatment for men with low-risk prostate cancer: a decision analysis.JAMA, 304 21
PA Ganz, JM Barry, W Burke (2012)
National Institutes of Health State-of-the-Science Conference: role of active surveillance in the management of men with localized prostate cancer., 156
E. Scosyrev, E. Messing, S. Mohile, D. Golijanin, Guan Wu (2011)
Prostate cancer in the elderly: frequency of advanced disease at presentation and disease-specific mortalityInternational Braz J Urol, 37
E. Scosyrev, E. Messing, S. Mohile, D. Golijanin, Guan Wu (2012)
Prostate cancer in the elderlyCancer, 118
M. Cooperberg, Sangtae Park, P. Carroll (2004)
Prostate cancer 2004: insights from national disease registries.Oncology, 18 10
Jennifer Yu, Mack Roach (2008)
Quality of life and satisfaction with outcome among prostate-cancer survivors.The New England journal of medicine, 359 2
T. Jang, O. Yossepowitch, F. Bianco, P. Scardino (2007)
Low risk prostate cancer in men under age 65: the case for definitive treatment.Urologic oncology, 25 6
M. Cooperberg, J. Broering, P. Carroll (2010)
Time trends and local variation in primary treatment of localized prostate cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28 7
I. Thompson, D. Ankerst, Chen Chi, P. Goodman, C. Tangen, M. Lucia, Ziding Feng, H. Parnes, C. Coltman (2006)
Assessing prostate cancer risk: results from the Prostate Cancer Prevention Trial.Journal of the National Cancer Institute, 98 8
T. Wilt, R. MacDonald, I. Rutks, T. Shamliyan, B. Taylor, R. Kane (2008)
Systematic Review: Comparative Effectiveness and Harms of Treatments for Clinically Localized Prostate CancerAnnals of Internal Medicine, 148
ImportanceMany men with indolent prostate cancer often opt for radical prostatectomy or radiotherapy treatment for their disease. These men may experience considerable detriments of quality of life owing to sexual, urinary, and/or rectal toxic effects associated with these treatments. Without a better understanding of the mutable agents and predictors of treatment types, diffusion of expectant management among these men will be slow. ObjectiveTo determine population-based predictors for treatment and use of watchful waiting or active surveillance for indolent prostate cancer. Design, Setting, and ParticipantsWe used Surveillance, Epidemiology, and End Results (SEER)–Medicare linked data. A total of 37 621 men in the general community diagnosed as having prostate cancer from 2004 to 2007 were followed until December 31, 2009. ExposuresWatchful waiting or active surveillance, radiation therapy, or radical prostatectomy. Main Outcomes and MeasuresWe used mixed-effects logistic regression analysis to determine the factors associated with aggressive treatment and use of watchful waiting or active surveillance for men with prostate cancer. ResultsThe most common treatment type is radiation therapy (57.9% [95% CI, 57.4%-58.4%]), followed by radical prostatectomy (19.1% [95% CI, 18.7%-19.5%]) and watchful waiting or active surveillance (9.6% [95% CI, 9.3%-9.9%]). Moreover, patients and providers significantly integrate age (odds ratio [OR], 0.32 [95% CI, 0.29–0.35]) and comorbidities (OR, 0.62 [95% CI, 0.56–0.68]) when determining radical prostatectomy, while regional variation (OR, 0.57 [95% CI, 0.47–0.68]) and referral patterns (OR, 44.46 [95% CI, 41.04–48.17]) influence the use of radiation therapy. Patient demographics and tumor characteristics significantly account for 40% of patients undergoing prostatectomy, 12% choosing watchful waiting or active surveillance, and only 3% undergoing radiotherapy. Conclusions and RelevanceThere is increased use of radiotherapy among patients with indolent prostate cancer with limited to no correlation with tumor biology. Active surveillance was underused, and a significant proportion of the variance was unexplained. Further research into qualitatively describing the contributing factors that drive decision-making recommendations for prostate cancer patients is needed.
JAMA Oncology – American Medical Association
Published: Apr 1, 2015
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