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Key PointsQuestionAre seizures more likely to occur during rewarming after hypothermia, and are they are associated with abnormal outcomes in asphyxiated neonates receiving hypothermia therapy? FindingsThis cohort study reports higher odds of electrographic seizure during the rewarming phase after hypothermia associated with increased relative risk of death or disability at 2-year follow-up. MeaningStudy findings support the American Clinical Neurophysiology Society’s Guidelines for continuous electroencephalography monitoring of neonates with suspected perinatal asphyxia during hypothermia and further suggest that monitoring should be continued until normothermia is completed and seizure control is assured.
JAMA Neurology – American Medical Association
Published: Dec 18, 2021
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