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RECOMBINANT ACTIVATED FACTOR VII -
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- Publisher
- American Medical Association
- Copyright
- Copyright 2019 American Medical Association. All Rights Reserved.
- ISSN
- 2168-6149
- eISSN
- 2168-6157
- DOI
- 10.1001/jamaneurol.2019.1141
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionDoes intensive blood pressure reduction decrease the risk of hematoma expansion and improve outcomes in patients with deep intracerebral hemorrhage? FindingsIn this exploratory analysis of the Antihypertensive Treatment of Acute Cerebral Hemorrhage–2 randomized clinical trial, intensive blood pressure reduction was associated with a decreased risk of hematoma expansion in deep intracerebral hemorrhage, and this association was driven by hemorrhages located in the basal ganglia. No association with outcome was found in this population. MeaningIntensive blood pressure reduction was associated with a decreased risk of hematoma expansion, an important neuroimaging marker of primary brain injury, in patients with intracerebral hemorrhage that compromises the basal ganglia; however, intensive blood pressure reduction was not associated with improved outcomes.
Journal
JAMA Neurology – American Medical Association
Published: Aug 13, 2019