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Association of Pallidal Neurostimulation and Outcome Predictors With X-linked Dystonia Parkinsonism

Association of Pallidal Neurostimulation and Outcome Predictors With X-linked Dystonia Parkinsonism Key PointsQuestionsIs deep brain stimulation (DBS) an efficient therapeutic option in severe X-linked dystonia parkinsonism and what are predictors for the postoperative outcome? FindingsIn this cohort study, pallidal DBS resulted in an improvement of dystonia and, to a lesser extent, parkinsonism. Deep brain stimulation was less effective in patients with more pronounced caudate atrophy. MeaningPallidal DBS should be considered a first-line treatment in medically intractable X-linked dystonia parkinsonism, and given the association of poorer treatment outcomes in patients with more advanced neurodegeneration, DBS should potentially be considered during the earlier stages of the disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

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References (17)

Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2018.3777
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionsIs deep brain stimulation (DBS) an efficient therapeutic option in severe X-linked dystonia parkinsonism and what are predictors for the postoperative outcome? FindingsIn this cohort study, pallidal DBS resulted in an improvement of dystonia and, to a lesser extent, parkinsonism. Deep brain stimulation was less effective in patients with more pronounced caudate atrophy. MeaningPallidal DBS should be considered a first-line treatment in medically intractable X-linked dystonia parkinsonism, and given the association of poorer treatment outcomes in patients with more advanced neurodegeneration, DBS should potentially be considered during the earlier stages of the disease.

Journal

JAMA NeurologyAmerican Medical Association

Published: Feb 3, 2019

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