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Key PointsQuestionsIs deep brain stimulation (DBS) an efficient therapeutic option in severe X-linked dystonia parkinsonism and what are predictors for the postoperative outcome? FindingsIn this cohort study, pallidal DBS resulted in an improvement of dystonia and, to a lesser extent, parkinsonism. Deep brain stimulation was less effective in patients with more pronounced caudate atrophy. MeaningPallidal DBS should be considered a first-line treatment in medically intractable X-linked dystonia parkinsonism, and given the association of poorer treatment outcomes in patients with more advanced neurodegeneration, DBS should potentially be considered during the earlier stages of the disease.
JAMA Neurology – American Medical Association
Published: Feb 3, 2019
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