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Key PointsQuestionTo what extent can the beneficial effect of endovascular therapy for acute ischemic stroke on functional outcome be explained by treatment-related reduced follow-up infarct volume? FindingsIn this pooled data mediation analysis of randomized clinical trials including 1665 patients with acute ischemic stroke, follow-up infarct volume reduction was a predictor of functional outcome but only explained 12% of the benefit of endovascular therapy. MeaningInfarct volume assessed on posttreatment imaging is currently not a valid proxy for estimating treatment effect in phase II and III trials.
JAMA Neurology – American Medical Association
Published: Feb 7, 2019
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