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Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke

Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up... Key PointsQuestionTo what extent can the beneficial effect of endovascular therapy for acute ischemic stroke on functional outcome be explained by treatment-related reduced follow-up infarct volume? FindingsIn this pooled data mediation analysis of randomized clinical trials including 1665 patients with acute ischemic stroke, follow-up infarct volume reduction was a predictor of functional outcome but only explained 12% of the benefit of endovascular therapy. MeaningInfarct volume assessed on posttreatment imaging is currently not a valid proxy for estimating treatment effect in phase II and III trials. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

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References (38)

Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2018.3661
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionTo what extent can the beneficial effect of endovascular therapy for acute ischemic stroke on functional outcome be explained by treatment-related reduced follow-up infarct volume? FindingsIn this pooled data mediation analysis of randomized clinical trials including 1665 patients with acute ischemic stroke, follow-up infarct volume reduction was a predictor of functional outcome but only explained 12% of the benefit of endovascular therapy. MeaningInfarct volume assessed on posttreatment imaging is currently not a valid proxy for estimating treatment effect in phase II and III trials.

Journal

JAMA NeurologyAmerican Medical Association

Published: Feb 7, 2019

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