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Apolipoprotein E genotype and sex risk factors for Alzheimer disease: a meta-analysis [published online August 28, 2017]
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Opinion EDITORIAL Apolipoprotein E ε4 and Risk Factors for Alzheimer Disease— Let’s Talk About Sex Dena B. Dubal, MD, PhD; Camille Rogine, BA The apolipoprotein E 4 (APOE4) allele is the most potent meta-analysis that includes more than 57 000 patients aged 55 to 85 years from 27 independent research studies. In addition to genetic risk factor for late-onset Alzheimer disease (AD) and female sex is associated with increased risk. In both sexes, car- power, their work adds the variable of time to our understand- riersoftheAPOE4alleleharbor ing of female vulnerability to APOE4. As expected, they con- a dose-dependent increase in firmed that APOE4 carriers (ε3/ε4) showed increased risk for de- risk of AD development, com- veloping MCI, AD, and MCI conversion to AD, regardless of sex. Related article page 1178 pared with those with the neu- Unexpectedly, they identified ages during which clinical, sex- tral APOE3 or protective APOE2. We understand the APOE4 risk based vulnerabilities emerge. Increased APOE4 risk in women to be greater in women, and our current dogma raises several compared with men was limited to ages 55 to 70 years for devel- questions. Is female vulnerability to APOE4 a robust association oping MCI and 65
JAMA Neurology – American Medical Association
Published: Oct 28, 2017
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