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Opinion EDITORIAL Association Between Serum Calcium Level and the Size and Expansion of Intracerebral Hemorrhage Mark J. Alberts, MD; Ravi Sarode, MD Intracerebral hemorrhage (ICH) is a common and deadly type elevated blood pressure, which could cause increased bleed- of stroke, with high rates of morbidity and mortality (40%- ing and increase the risk of hematoma expansion. They dis- 1,2 50% in most series). There are several well-described and count this mechanism because their study cohort did not show validated risk factors and dis- a link between blood pressure on admission and hematoma eases that increase the risk of size. Furthermore, the volume of a deep hemorrhage (which ICH, including race, hyper- is typically related to hypertension) is not related to a low cal- Related article page 1285 tension, use of anticoagu- cium level. Other studies have failed to find an association be- lants, amyloid angiopathy, renal insufficiency, thrombolytic tween blood pressure and ICH expansion. We would also dis- therapy, and drug abuse. However, not all ICHs are associ- count a relationship between calcium level, blood pressure, ated with one of these risk factors. This suggests that there and ICH status because small cerebral vessels are typically un- might
JAMA Neurology – American Medical Association
Published: Nov 6, 2016
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