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Surgical Treatment of Temporal Lobe Epilepsy

Surgical Treatment of Temporal Lobe Epilepsy Letters chotic use in PD is not associated with increased mortality, it is important to note that this study had a relatively small Type and Extent of Surgery Matters sample size, was conducted at a single center, was not To the Editor I read with interest the evidence-based review by designed to examine short-term antipsychotic mortality Jones and Cascino. The authors performed a systematic re- risk, and only had a total of 47 patients treated with an anti- view of 27 studies with 3163 patients who underwent epi- psychotic at any time during the long-term observation lepsy surgery and demonstrated that magnetic resonance ima- period. ging–identified mesial temporal sclerosis is associated with a We agree with Malaty et al that our findings cannot be favorable outcome after surgery, while there is paucity of evi- considered conclusive, additional research is needed, and dence of the usefulness of positron emission tomography and studies comparing patients with PD and psychosis taking single-photon emission computed tomography in selecting pa- and not taking antipsychotics would provide important tients for epilepsy surgery. insight. However, observational studies comparing patients There are 2 important considerations with regard to sur- taking and not taking antipsychotics will not be http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Surgical Treatment of Temporal Lobe Epilepsy

Nabavizadeh, S. Ali
JAMA Neurology , Volume 73 (9) – Sep 18, 2016
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References (3)

Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2016.1847
pmid
27428396
Publisher site
See Article on Publisher Site

Abstract

Letters chotic use in PD is not associated with increased mortality, it is important to note that this study had a relatively small Type and Extent of Surgery Matters sample size, was conducted at a single center, was not To the Editor I read with interest the evidence-based review by designed to examine short-term antipsychotic mortality Jones and Cascino. The authors performed a systematic re- risk, and only had a total of 47 patients treated with an anti- view of 27 studies with 3163 patients who underwent epi- psychotic at any time during the long-term observation lepsy surgery and demonstrated that magnetic resonance ima- period. ging–identified mesial temporal sclerosis is associated with a We agree with Malaty et al that our findings cannot be favorable outcome after surgery, while there is paucity of evi- considered conclusive, additional research is needed, and dence of the usefulness of positron emission tomography and studies comparing patients with PD and psychosis taking single-photon emission computed tomography in selecting pa- and not taking antipsychotics would provide important tients for epilepsy surgery. insight. However, observational studies comparing patients There are 2 important considerations with regard to sur- taking and not taking antipsychotics will not be

Journal

JAMA Neurology – American Medical Association

Published: Sep 18, 2016

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