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Multiple System Atrophy and Repeat Expansions in C9orf72—Reply

Multiple System Atrophy and Repeat Expansions in C9orf72—Reply Letters Pesticides, including dichlorodiphenyltrichloroethane esis that the mechanism by which pesticide exposure may con- (DDT), and particularly their breakdown product DDE have tribute to Alzheimer and Parkinson diseases is through an 2 3 been linked with both Alzheimer and Parkinson diseases. The antitestosterone effect. This hypothesis appears to be based exact mechanism of action has been intensely researched, with on several cited review articles suggesting that androgens may some favoring a direct action of the different toxins on the neu- play a role in cognitive aging and in the etiology of Alzheimer rones and others an indirect action via their ability to induce disease. Furthermore, Martins and Carruthers cite an article oxidative stress, mitochondrial dysfunction, and α-synuclein from 20 years ago regarding the antiandrogenenic effects of fibrillization. However, there is general agreement that expo- dichlorodiphenyldichloroethylene (DDE). On close inspec- sure to multiple pesticides, genetic factors, and traumatic brain tion of the article, the dose or levels of DDE required to pro- injury can also predispose an individual to getting 1 or both of duce modest effects on androgen receptor binding and anti- these conditions. androgenic effects are orders of magnitude higher than the A mechanism we would like to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Multiple System Atrophy and Repeat Expansions in C9orf72—Reply

JAMA Neurology , Volume 71 (9) – Sep 1, 2014

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References (6)

Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2014.1811
pmid
25200544
Publisher site
See Article on Publisher Site

Abstract

Letters Pesticides, including dichlorodiphenyltrichloroethane esis that the mechanism by which pesticide exposure may con- (DDT), and particularly their breakdown product DDE have tribute to Alzheimer and Parkinson diseases is through an 2 3 been linked with both Alzheimer and Parkinson diseases. The antitestosterone effect. This hypothesis appears to be based exact mechanism of action has been intensely researched, with on several cited review articles suggesting that androgens may some favoring a direct action of the different toxins on the neu- play a role in cognitive aging and in the etiology of Alzheimer rones and others an indirect action via their ability to induce disease. Furthermore, Martins and Carruthers cite an article oxidative stress, mitochondrial dysfunction, and α-synuclein from 20 years ago regarding the antiandrogenenic effects of fibrillization. However, there is general agreement that expo- dichlorodiphenyldichloroethylene (DDE). On close inspec- sure to multiple pesticides, genetic factors, and traumatic brain tion of the article, the dose or levels of DDE required to pro- injury can also predispose an individual to getting 1 or both of duce modest effects on androgen receptor binding and anti- these conditions. androgenic effects are orders of magnitude higher than the A mechanism we would like to

Journal

JAMA NeurologyAmerican Medical Association

Published: Sep 1, 2014

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