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S. Lesage, I. Ber, C. Condroyer, E. Broussolle, A. Gabelle, S. Thobois, F. Pasquier, K. Mondon, P. Dion, D. Rochefort, G. Rouleau, A. Dürr, A. Brice (2013)
C9orf72 repeat expansions are a rare genetic cause of parkinsonism.Brain : a journal of neurology, 136 Pt 2
Davina Moss, M. Poulter, J. Beck, J. Hehir, J. Polke, T. Campbell, G. Adamson, E. Mudanohwo, P. McColgan, A. Haworth, E. Wild, M. Sweeney, H. Houlden, S. Mead, S. Tabrizi (2014)
C9orf72 expansions are the most common genetic cause of Huntington disease phenocopiesNeurology, 82
H. Uchikado, A. Delledonne, R. Uitti, D. Dickson (2006)
Coexistence of PSP and MSA: a case report and review of the literatureActa Neuropathologica, 111
A Robinson, Y Davidson, JS Snowden, DM Mann
C9ORF72 in dementia with lewy bodies [published online March 19, 2014].
J. Goldman, C. Quinzii, Jane Dunning-Broadbent, C. Waters, H. Mitsumoto, T. Brannagan, Stephanie Cosentino, E. Huey, P. Nagy, S. Kuo (2014)
Multiple system atrophy and amyotrophic lateral sclerosis in a family with hexanucleotide repeat expansions in C9orf72.JAMA neurology, 71 6
Sirinan Tazen, K. Figueroa, J. Kwan, J. Goldman, A. Hunt, J. Sampson, L. Gutmann, S. Pulst, H. Mitsumoto, S. Kuo (2013)
Amyotrophic lateral sclerosis and spinocerebellar ataxia type 2 in a family with full CAG repeat expansions of ATXN2.JAMA neurology, 70 10
Letters Pesticides, including dichlorodiphenyltrichloroethane esis that the mechanism by which pesticide exposure may con- (DDT), and particularly their breakdown product DDE have tribute to Alzheimer and Parkinson diseases is through an 2 3 been linked with both Alzheimer and Parkinson diseases. The antitestosterone effect. This hypothesis appears to be based exact mechanism of action has been intensely researched, with on several cited review articles suggesting that androgens may some favoring a direct action of the different toxins on the neu- play a role in cognitive aging and in the etiology of Alzheimer rones and others an indirect action via their ability to induce disease. Furthermore, Martins and Carruthers cite an article oxidative stress, mitochondrial dysfunction, and α-synuclein from 20 years ago regarding the antiandrogenenic effects of fibrillization. However, there is general agreement that expo- dichlorodiphenyldichloroethylene (DDE). On close inspec- sure to multiple pesticides, genetic factors, and traumatic brain tion of the article, the dose or levels of DDE required to pro- injury can also predispose an individual to getting 1 or both of duce modest effects on androgen receptor binding and anti- these conditions. androgenic effects are orders of magnitude higher than the A mechanism we would like to
JAMA Neurology – American Medical Association
Published: Sep 1, 2014
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