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Finding Benefit in n-of-1 Trials

Finding Benefit in n-of-1 Trials Letters nation diet is indeed standard of care. Compliance with the applied informally in the service of better, more patient- 6-food elimination diet in real-world settings is understandably centered care. low. Some recommend repeat EGDs at each step of the elimina- More generally, we believe that rumors of the demise of tion diet, for up to 5 EGDs per patient, at an immense burden n-of-1 trials may be premature for 3 reasons. First, advances to patients and expense to the health care system. in mobile technology and ubiquitous home and environmental My review also revealed that the most common food trig- sensors will increasingly make tracking and self-experimen- ger was dairy. This seemed a perfect situation for an un- tation much less demanding of time and effort on the part of blinded n-of-1 trial. The condition is chronic. Response to food both patients and clinicians. Second, n-of-1 trials retain prom- elimination varies by individual. The symptoms are experi- ise not only for evaluating treatment benefits in individual pa- enced near daily. And if I was going to eliminate a food from tients, but also (as Vohra and Punja suggest) for comparing my diet for the rest of my life, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Finding Benefit in n-of-1 Trials

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References (4)

Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/jamainternmed.2018.8382
Publisher site
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Abstract

Letters nation diet is indeed standard of care. Compliance with the applied informally in the service of better, more patient- 6-food elimination diet in real-world settings is understandably centered care. low. Some recommend repeat EGDs at each step of the elimina- More generally, we believe that rumors of the demise of tion diet, for up to 5 EGDs per patient, at an immense burden n-of-1 trials may be premature for 3 reasons. First, advances to patients and expense to the health care system. in mobile technology and ubiquitous home and environmental My review also revealed that the most common food trig- sensors will increasingly make tracking and self-experimen- ger was dairy. This seemed a perfect situation for an un- tation much less demanding of time and effort on the part of blinded n-of-1 trial. The condition is chronic. Response to food both patients and clinicians. Second, n-of-1 trials retain prom- elimination varies by individual. The symptoms are experi- ise not only for evaluating treatment benefits in individual pa- enced near daily. And if I was going to eliminate a food from tients, but also (as Vohra and Punja suggest) for comparing my diet for the rest of my life,

Journal

JAMA Internal Medicine – American Medical Association

Published: Mar 1, 2019

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