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JU Jensen, L Hein, B Lundgren (2011)
Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial, 39
Rafael Diaz-Flores (2012)
A letter in response to: Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial.Critical care medicine, 40 3
F. Bloos, E. Trips, A. Nierhaus, J. Briegel, D. Heyland, U. Jaschinski, O. Moerer, A. Weyland, G. Marx, M. Gründling, S. Kluge, I. Kaufmann, Klaus Ott, M. Quintel, F. Jelschen, P. Meybohm, S. Rademacher, A. Meier‑Hellmann, S. Utzolino, U. Kaisers, C. Putensen, G. Elke, M. Ragaller, H. Gerlach, K. Ludewig, M. Kiehntopf, H. Bogatsch, C. Engel, F. Brunkhorst, M. Loeffler, K. Reinhart (2016)
Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial.JAMA internal medicine, 176 9
E. Jong, J. Oers, A. Beishuizen, P. Vos, W. Vermeijden, L. Haas, B. Loef, T. Dormans, G. Melsen, Yvette Kluiters, H. Kemperman, M. Elsen, J. Schouten, J. Streefkerk, H. Krabbe, H. Kieft, G. Kluge, Veerle Dam, Joost Pelt, L. Bormans, M. Otten, A. Reidinga, H. Endeman, J. Twisk, E. Garde, A. Smet, J. Kesecioglu, A. Girbes, M. Nijsten, D. Lange (2016)
Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial.The Lancet. Infectious diseases, 16 7
Letters Funding/Support: This project was not supported by any external grants or sicians refrained from stopping antibiotics in high-risk funds. Mr Gupta is supported by the Yale University School of Medicine Office of patients, such as patients with septic shock. In the SAPS Student Research. Dr Kesselheim is supported by the Laura and John Arnold trial, we compared the characteristics of the patients evalu- Foundation and the Harvard Program in Therapeutic Science. ated with the algorithm vs those who were not. The percent- Role of the Funder/Sponsor: The funders/sponsors had no role in the design age of septic shock was the same in both groups and Acute and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to Physiology and Chronic Health Evaluation IV and SOFA submit the manuscript for publication. scores at inclusion were lower in those who were not evalu- Additional Contributions: The authors would like to acknowledge the ated by the algorithm. It seems physicians do not want to contributions of Jeremy Greene, MD, PhD, of the Johns Hopkins University rely completely on PCT levels. We understand that the high School of Medicine, Baltimore,
JAMA Internal Medicine – American Medical Association
Published: Jan 1, 2017
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