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Letters 2. Charytan D, Kuntz RE. The exclusion of patients with chronic kidney disease issue guidelines on the inclusion of women in clinical trials. from clinical trials in coronary artery disease. Kidney Int. 2006;70(11):2021-2030. Given that KD is highly prevalent and may modify relevant 3. Konstantinidis I, Nadkarni GN, Yacoub R, et al. Representation of patients parameters of some medications or procedures (eg, efficacy, with kidney disease in trials of cardiovascular interventions: an updated safety, and pharmacokinetics), patients with KD should be in- systematic review [published online November 30, 2015]. JAMA Intern Med. cluded in cardiovascular trials in the absence of absolute con- doi:10.1001/jamainternmed.2015.6102. traindications. Investigators’ goal should be to enroll a study 4. Tomey MI, Winston JA. Cardiovascular pathophysiology in chronic kidney disease: opportunities to transition from disease to health. Ann Glob Health. population in which the prevalence and severity of KD match 2014;80(1):69-76. the prevalence and severity in the target population. Further- 5. Chertow GM, Normand SL, McNeil BJ. “Renalism”: inappropriately low rates more, investigators should consider stratifying treatment as- of coronary angiography in elderly individuals with renal insufficiency. J Am Soc signment based on kidney function to achieve balance and Nephrol. 2004;15(9):2462-2468. should report outcome and
JAMA Internal Medicine – American Medical Association
Published: Jan 1, 2016
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