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Letters Author Affiliations: Diabetes Centre, Isala Clinics, Zwolle, the Netherlands In Reply We want to thank Huang and Subak for their interest in 1 (Landman, van Hateren, Kleefstra); Department of Internal Medicine, University our study. They state that we should not have made strong con- Medical Center Groningen, Groningen, the Netherlands (Kleefstra); Langerhans clusions concerning nonefficacy based on results extending out- Medical Research Group, Zwolle, the Netherlands (Kleefstra). side the present study and that we performed an underpowered Corresponding Author: Gijs W. D. Landman, MD, PhD, Diabetes Centre, Isala studywithmethodologicallimitationsandunsuccessfulrandom- Clinics, PO Box 10400, 8000GKZwolle,the Netherlands (g.w.d.landman @isala.nl). ization. We respectfully disagree with all their statements. Conflict of Interest Disclosures: None reported. Wedoagreewiththeirlastsentence“broadconclusionsabout nonefficacy of device-guided breathing are not supported by this 1. Landman GW, Drion I, van Hateren KJ, et al. Device-guided breathing as treatment for hypertension in type 2 diabetes mellitus: a randomized, study alone.” Nonefficacy was also the result of 2 other trials per- double-blind, sham-controlled trial. JAMA Intern Med. 2013;173(14):1346-1350. 2,3 formed by our research group. A recent meta-analysis, specifi- 2. Logtenberg SJ, Kleefstra N, Houweling ST, Groenier KH, Bilo HJ. Effect of callyinstudieswithsufficientmethodologicalquality,confirmed device-guided breathing exercises on blood pressure in hypertensive patients thatthereisnoevidenceforshort-termeffectsonbloodpressure. with
JAMA Internal Medicine – American Medical Association
Published: Apr 1, 2014
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