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Assessment of Age, Period, and Birth Cohort Effects and Trends in Merkel Cell Carcinoma Incidence in the United States

Assessment of Age, Period, and Birth Cohort Effects and Trends in Merkel Cell Carcinoma Incidence... Key PointsQuestionWhat are the associations of age, calendar period of diagnosis, and birth cohort with the increasing incidence of Merkel cell carcinoma (MCC), and how can they inform projected incidence rates? FindingsThis cross-sectional study of 3720 patients with MCC found that, although birth cohort effects continue to increase over time, the effect owing to period of diagnosis has started to plateau. The projected incidence rate is estimated to be 3023 new cases of MCC in 2020. MeaningThe initial increase found in this cross-sectional study in the incidence of MCC was likely owing in part to increased detection (period effect), but the continued increase will likely be associated with changes in risk factors (birth cohort effects) and the aging population (age effects). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Assessment of Age, Period, and Birth Cohort Effects and Trends in Merkel Cell Carcinoma Incidence in the United States

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References (33)

Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2020.4102
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat are the associations of age, calendar period of diagnosis, and birth cohort with the increasing incidence of Merkel cell carcinoma (MCC), and how can they inform projected incidence rates? FindingsThis cross-sectional study of 3720 patients with MCC found that, although birth cohort effects continue to increase over time, the effect owing to period of diagnosis has started to plateau. The projected incidence rate is estimated to be 3023 new cases of MCC in 2020. MeaningThe initial increase found in this cross-sectional study in the incidence of MCC was likely owing in part to increased detection (period effect), but the continued increase will likely be associated with changes in risk factors (birth cohort effects) and the aging population (age effects).

Journal

JAMA DermatologyAmerican Medical Association

Published: Jan 4, 2021

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