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Key PointsQuestionWhat are the associations of age, calendar period of diagnosis, and birth cohort with the increasing incidence of Merkel cell carcinoma (MCC), and how can they inform projected incidence rates? FindingsThis cross-sectional study of 3720 patients with MCC found that, although birth cohort effects continue to increase over time, the effect owing to period of diagnosis has started to plateau. The projected incidence rate is estimated to be 3023 new cases of MCC in 2020. MeaningThe initial increase found in this cross-sectional study in the incidence of MCC was likely owing in part to increased detection (period effect), but the continued increase will likely be associated with changes in risk factors (birth cohort effects) and the aging population (age effects).
JAMA Dermatology – American Medical Association
Published: Jan 4, 2021
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