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A Variant of AESOP Syndrome (Adenopathy and Extensive Skin Patch Overlying a Plasmacytoma)—Reply

A Variant of AESOP Syndrome (Adenopathy and Extensive Skin Patch Overlying a Plasmacytoma)—Reply In Reply We thank you for your letter and interest in our report of a patient with a variant of the AESOP syndrome.1 The histologic features of the cutaneous manifestation of AESOP syndrome alone are nondiagnostic. Our patient’s cutaneous lesions and lymphadenopathy are consistent with the clinical features of AESOP syndrome, and they resolved with treatment of the underlying malignant neoplasm. As you have mentioned, the underlying neoplasm in this case was a Ewing sarcomalike malignant blue-cell tumor, which, unlike plasmacytoma, may result in production of different cytokines, leading to a variation in the histopathologic findings of the cutaneous lesion. While there are certain histologic features that may raise the question of a multinucleated-cell angiohistiocytoma, those lesions tend to manifest in acral locations and are not associated with an underlying malignant neoplasm, unlike that in our case, which had the clinical features consistent with a variant of the AESOP syndrome. Back to top Article Information Corresponding Author: Chong Wee Foo, MD, University of Utah, Department of Dermatology, 4A330 School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132 (chong.foo@hsc.utah.edu). References 1. Foo CW, Florell SR, Petersen MJ. A variant of AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma) in a malignant blue-cell tumor. Arch Dermatol. 2012;148(12):1431-1432.PubMedGoogle ScholarCrossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

A Variant of AESOP Syndrome (Adenopathy and Extensive Skin Patch Overlying a Plasmacytoma)—Reply

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References (1)

Publisher
American Medical Association
Copyright
Copyright © 2013 American Medical Association. All Rights Reserved.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2013.4776
Publisher site
See Article on Publisher Site

Abstract

In Reply We thank you for your letter and interest in our report of a patient with a variant of the AESOP syndrome.1 The histologic features of the cutaneous manifestation of AESOP syndrome alone are nondiagnostic. Our patient’s cutaneous lesions and lymphadenopathy are consistent with the clinical features of AESOP syndrome, and they resolved with treatment of the underlying malignant neoplasm. As you have mentioned, the underlying neoplasm in this case was a Ewing sarcomalike malignant blue-cell tumor, which, unlike plasmacytoma, may result in production of different cytokines, leading to a variation in the histopathologic findings of the cutaneous lesion. While there are certain histologic features that may raise the question of a multinucleated-cell angiohistiocytoma, those lesions tend to manifest in acral locations and are not associated with an underlying malignant neoplasm, unlike that in our case, which had the clinical features consistent with a variant of the AESOP syndrome. Back to top Article Information Corresponding Author: Chong Wee Foo, MD, University of Utah, Department of Dermatology, 4A330 School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132 (chong.foo@hsc.utah.edu). References 1. Foo CW, Florell SR, Petersen MJ. A variant of AESOP syndrome (adenopathy and extensive skin patch overlying a plasmacytoma) in a malignant blue-cell tumor. Arch Dermatol. 2012;148(12):1431-1432.PubMedGoogle ScholarCrossref

Journal

JAMA Dermatology – American Medical Association

Published: Sep 1, 2013

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