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- Publisher
- American Medical Association
- Copyright
- Copyright 2021 American Medical Association. All Rights Reserved.
- ISSN
- 2380-6583
- eISSN
- 2380-6591
- DOI
- 10.1001/jamacardio.2021.3187
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionWhat is the association of intensive systolic blood pressure lowering with the risk of heart failure and mortality among individuals with elevated high-sensitivity cardiac troponin T (hscTnT) and N-terminal pro–B-type natriuretic peptide (NTproBNP) levels? FindingsIn this nonprespecified post hoc analysis of the Systolic Blood Pressure Intervention Trial randomized clinical trial, intensive systolic blood pressure lowering was associated with an 8% absolute risk reduction in heart failure and mortality among individuals with elevation in both hscTnT and NTproBNP levels, compared with a 2% absolute risk reduction among individuals without elevated markers. MeaningThe risk associated with elevated hscTnT and NTproBNP levels may be modifiable with intensive systolic blood pressure lowering.
Journal
JAMA Cardiology – American Medical Association
Published: Dec 1, 2021