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Key PointsQuestionWhat is the association of a triple pill containing low doses of 3 antihypertensive medications with therapeutic inertia compared with usual care? FindingsIn this secondary analysis of a randomized clinical trial including 700 patients with mild to moderate hypertension, rates of therapeutic inertia were significantly different between those in the triple pill group and those in the usual care group at the week 6 visit (92 of 106 [86.8%] vs 124 of 194 [63.9%]) and the week 12 visit (81 of 90 [90%] vs 116 of 179 [64.8%]). Compared with those in the usual care group, significantly more patients in the triple pill group achieved blood pressure targets (221 of 318 [69.5%] vs 182 of 329 [55.3%]) with significantly fewer unique antihypertensive treatment regimens (23 vs 54 per 100 treated patients). MeaningUse of a low-dose triple combination antihypertensive medication improves blood pressure control and simplifies treatment regimen but is associated with increased therapeutic inertia.
JAMA Cardiology – American Medical Association
Published: Nov 22, 2020
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