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Improvement of Cardiovascular Functional Reserve After Kidney Transplant—Has the CAPER Been Solved?

Improvement of Cardiovascular Functional Reserve After Kidney Transplant—Has the CAPER Been Solved? Research Original Investigation Cardiovascular Functional Reserve Before and After Kidney Transplant Invited Commentary Improvement of Cardiovascular Functional Reserve After Kidney Transplant— Has the CAPER Been Solved? George L. Bakris, MD; Michelle A. Josephson, MD In this issue of JAMA Cardiology, Lim and colleagues report ated 70 adult patients within 4 weeks before kidney trans- on cardiovascular functional reserve in people with end- plant. Echocardiography, CPET, and arterial applanation to- stage renal disease before and after kidney transplant. They nometry were performed. Reduced anerobic threshold was the performed a 3-arm, prospec- most significant indicator of mortality. This same group ex- tive, concurrent cohort study panded their hypothesis of reduced anerobic threshold indi- Related article page 420 cating poor outcomes in kidney transplant recipients by evalu- to assess change in cardiovas- cular functional reserve af- ating 240 individuals wait-listed for kidney transplant who ter kidney transplant using state-of-the-art cardiopulmonary were followed up for up to 5 years. Survival was the primary exercise testing (CPET). They also assessed left ventricular mor- end point. Cumulative survival for the entire cohort was 72.6%, phologic findings 1 year after transplant. They enrolled 81 par- with cardiovascular events being the most common cause of ticipants with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Cardiology American Medical Association

Improvement of Cardiovascular Functional Reserve After Kidney Transplant—Has the CAPER Been Solved?

JAMA Cardiology , Volume 5 (4) – Apr 5, 2020

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References (9)

Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2380-6583
eISSN
2380-6591
DOI
10.1001/jamacardio.2019.5874
Publisher site
See Article on Publisher Site

Abstract

Research Original Investigation Cardiovascular Functional Reserve Before and After Kidney Transplant Invited Commentary Improvement of Cardiovascular Functional Reserve After Kidney Transplant— Has the CAPER Been Solved? George L. Bakris, MD; Michelle A. Josephson, MD In this issue of JAMA Cardiology, Lim and colleagues report ated 70 adult patients within 4 weeks before kidney trans- on cardiovascular functional reserve in people with end- plant. Echocardiography, CPET, and arterial applanation to- stage renal disease before and after kidney transplant. They nometry were performed. Reduced anerobic threshold was the performed a 3-arm, prospec- most significant indicator of mortality. This same group ex- tive, concurrent cohort study panded their hypothesis of reduced anerobic threshold indi- Related article page 420 cating poor outcomes in kidney transplant recipients by evalu- to assess change in cardiovas- cular functional reserve af- ating 240 individuals wait-listed for kidney transplant who ter kidney transplant using state-of-the-art cardiopulmonary were followed up for up to 5 years. Survival was the primary exercise testing (CPET). They also assessed left ventricular mor- end point. Cumulative survival for the entire cohort was 72.6%, phologic findings 1 year after transplant. They enrolled 81 par- with cardiovascular events being the most common cause of ticipants with

Journal

JAMA CardiologyAmerican Medical Association

Published: Apr 5, 2020

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