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Key PointsQuestionDoes obesity mediate response to sodium channel vs potassium channel blocker antiarrhythmic drugs in patients with atrial fibrillation and in mice with diet-induced obesity? FindingsIn this cohort study of 311 patients, those with obesity had greater recurrence (30%) of atrial fibrillation compared with those who were not obese who received sodium channel blocker antiarrhythmic drugs (6%); significant factors associated with failure to respond to antiarrhythmic drugs were use of sodium channel blockers, obesity, female sex, and hyperthyroidism. Mice with obesity showed reduced association of flecainide acetate in suppressing pacing-induced atrial fibrillation vs sotalol hydrochloride. MeaningPossible reduced response to sodium channel blocker antiarrhythmic drugs in suppressing atrial fibrillation in patients with obesity has important clinical implications.
JAMA Cardiology – American Medical Association
Published: Jan 27, 2020
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