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- Publisher
- American Medical Association
- Copyright
- Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 2380-6583
- eISSN
- 2380-6591
- DOI
- 10.1001/jamacardio.2016.0765
- pmid
- 27439107
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionWhat is the association between temporal change in high-sensitivity cardiac troponin T (hs-cTnT), which reflects trajectory of subclinical myocardial damage, and subsequent cardiovascular outcomes? FindingsIn this cohort of 8838 adults, 6-year change in hs-cTnT was associated with subsequent coronary heart disease, heart failure (HF) (including both HF with reduced ejection fraction and HF with preserved ejection fraction subtypes), and death. Repeat hs-cTnT testing improved discrimination and net reclassification of HF and death, adding to traditional risk factors, N-terminal pro–brain natriuretic peptide, and baseline hs-cTnT level. MeaningTwo measurements of hs-cTnT appear to be better than 1 measurement for characterizing risk and may augment targeted prevention efforts, especially among adults with stage A or B HF.
Journal
JAMA Cardiology – American Medical Association
Published: Aug 1, 2016