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Medical Challenges of Improving the Quality of a Longer Life

Medical Challenges of Improving the Quality of a Longer Life COMMENTARY Medical Challenges of Improving the Quality of a Longer Life should be considered with a life-course perspective from con- Jean-Pierre Michel, MD ception to extreme old age. This message is underscored Julia L. Newton, MD by increasing understanding of the biological processes re- Thomas B. L. Kirkwood, PhD sponsible for intrinsic aging, which results from the gradual, lifelong accumulation of molecular and cellular damage. HEN GERIATRICIANS AND GERONTOLOGIST RE- A wealth of experimental data indicates that the damage that searchers consider the health challenges that will eventually give rise to adverse health outcomes in old will affect the global population in coming age is accumulating from the earliest stages of life. This raises Wdecades, their reactions most often combine the exciting prospect that if medical and social interven- alarm with a determination for action. Based on current tions can be identified that reduce the rate of damage ac- demographic forecasts and the age-incidence patterns of ma- cumulation, it may be possible to exploit the intrinsic mal- jor age-related diseases, the prospects for greatly in- leability of the aging process. Such malleability is revealed creased prevalence of age-related frailty and disability can not only in animal models but also http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Medical Challenges of Improving the Quality of a Longer Life

Michel, Jean-Pierre; Newton, Julia L.; Kirkwood, Thomas B. L.
JAMA , Volume 299 (6) – Feb 13, 2008
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References (26)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.299.6.688
pmid
18270358
Publisher site
See Article on Publisher Site

Abstract

COMMENTARY Medical Challenges of Improving the Quality of a Longer Life should be considered with a life-course perspective from con- Jean-Pierre Michel, MD ception to extreme old age. This message is underscored Julia L. Newton, MD by increasing understanding of the biological processes re- Thomas B. L. Kirkwood, PhD sponsible for intrinsic aging, which results from the gradual, lifelong accumulation of molecular and cellular damage. HEN GERIATRICIANS AND GERONTOLOGIST RE- A wealth of experimental data indicates that the damage that searchers consider the health challenges that will eventually give rise to adverse health outcomes in old will affect the global population in coming age is accumulating from the earliest stages of life. This raises Wdecades, their reactions most often combine the exciting prospect that if medical and social interven- alarm with a determination for action. Based on current tions can be identified that reduce the rate of damage ac- demographic forecasts and the age-incidence patterns of ma- cumulation, it may be possible to exploit the intrinsic mal- jor age-related diseases, the prospects for greatly in- leability of the aging process. Such malleability is revealed creased prevalence of age-related frailty and disability can not only in animal models but also

Journal

JAMA – American Medical Association

Published: Feb 13, 2008

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