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CETP Genes, Metabolic Effects, and Coronary Disease Risk

CETP Genes, Metabolic Effects, and Coronary Disease Risk Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. CETP Genes, Metabolic Effects, and Coronary Disease Risk chemical phenotypes related to CETP metabolism, HDL- Peter W. F. Wilson, MD cholesterol (HDL-C) level (a traditional risk factor for which the blood level is partly determined by CETP activity), and HE BURDEN OF ATHEROSCLEROTIC CORONARY HEART CHD risk estimates. disease (CHD) is tremendous—both genes and The CETP genotype relationship to CHD risk reported environment contribute to this problem. From a by Thompson et al is similar to that reported in a meta- Tclinical perspective, physicians are well aware of analysis that focused on the CETP TaqIB variants. The study the importance of genetic lipid abnormalities in the causa- 1 by Thompson et al answers the call for a comprehensive tion of CHD. The best studied genetic lipid abnormality analysis of the gene effects related to CETP, its metabo- is familial hypercholesterolemia (FH), which can cause lites, and CHD risk, and differs from previous analyses by clinical findings such as xanthomas, early atherosclerosis, including much more data, especially concerning the in- and premature CHD. Approximately 1 out of 500 of the termediate biomarkers http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

CETP Genes, Metabolic Effects, and Coronary Disease Risk

JAMA , Volume 299 (23) – Jun 18, 2008

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References (15)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.299.23.2795
pmid
18560008
Publisher site
See Article on Publisher Site

Abstract

Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. CETP Genes, Metabolic Effects, and Coronary Disease Risk chemical phenotypes related to CETP metabolism, HDL- Peter W. F. Wilson, MD cholesterol (HDL-C) level (a traditional risk factor for which the blood level is partly determined by CETP activity), and HE BURDEN OF ATHEROSCLEROTIC CORONARY HEART CHD risk estimates. disease (CHD) is tremendous—both genes and The CETP genotype relationship to CHD risk reported environment contribute to this problem. From a by Thompson et al is similar to that reported in a meta- Tclinical perspective, physicians are well aware of analysis that focused on the CETP TaqIB variants. The study the importance of genetic lipid abnormalities in the causa- 1 by Thompson et al answers the call for a comprehensive tion of CHD. The best studied genetic lipid abnormality analysis of the gene effects related to CETP, its metabo- is familial hypercholesterolemia (FH), which can cause lites, and CHD risk, and differs from previous analyses by clinical findings such as xanthomas, early atherosclerosis, including much more data, especially concerning the in- and premature CHD. Approximately 1 out of 500 of the termediate biomarkers

Journal

JAMAAmerican Medical Association

Published: Jun 18, 2008

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