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Epigenetics at the Epicenter of Modern Medicine

Epigenetics at the Epicenter of Modern Medicine SPECIAL COMMUNICATION Epigenetics at the Epicenter of Modern Medicine Andrew P. Feinberg, MD, MPH Epigenetics, the study of non-DNA sequence−related heredity, is at the epi- center of modern medicine because it can help to explain the relationship What Is Epigenetics? between an individual’s genetic background, the environment, aging, and Although epigenetics is considered a disease. It can do so because the epigenetic state varies among tissues and relatively new area of medicine, the during a lifetime, whereas the DNA sequence remains essentially the same. term is more than 60 years old. Wad- As cells adapt to a changing internal and external environment, epigenetic dington first used the term epigenetics mechanisms can remember these changes in the normal programming and to describe what is now called devel- reprogramming of gene activity. The common disease genetic and epige- opmental biology, the idea that pheno- netic (CDGE) model provides an epidemiologic framework that can incor- type, or the morphologic and func- tional properties of an organism, arises porate epigenetic with genetic variation in the context of age-related sus- sequentially under a program defined ceptibility to disease. Under CDGE, the epigenetic program can modify the by the genome under the influence of effects http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Epigenetics at the Epicenter of Modern Medicine

JAMA , Volume 299 (11) – Mar 19, 2008

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References (42)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.299.11.1345
pmid
18349095
Publisher site
See Article on Publisher Site

Abstract

SPECIAL COMMUNICATION Epigenetics at the Epicenter of Modern Medicine Andrew P. Feinberg, MD, MPH Epigenetics, the study of non-DNA sequence−related heredity, is at the epi- center of modern medicine because it can help to explain the relationship What Is Epigenetics? between an individual’s genetic background, the environment, aging, and Although epigenetics is considered a disease. It can do so because the epigenetic state varies among tissues and relatively new area of medicine, the during a lifetime, whereas the DNA sequence remains essentially the same. term is more than 60 years old. Wad- As cells adapt to a changing internal and external environment, epigenetic dington first used the term epigenetics mechanisms can remember these changes in the normal programming and to describe what is now called devel- reprogramming of gene activity. The common disease genetic and epige- opmental biology, the idea that pheno- netic (CDGE) model provides an epidemiologic framework that can incor- type, or the morphologic and func- tional properties of an organism, arises porate epigenetic with genetic variation in the context of age-related sus- sequentially under a program defined ceptibility to disease. Under CDGE, the epigenetic program can modify the by the genome under the influence of effects

Journal

JAMAAmerican Medical Association

Published: Mar 19, 2008

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