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Glycemic Variability: A Hemoglobin A1c–Independent Risk Factor for Diabetic Complications

Glycemic Variability: A Hemoglobin A1c–Independent Risk Factor for Diabetic Complications Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. Glycemic Variability: A Hemoglobin A – 1c Independent Risk Factor for Diabetic Complications Considering these facts, an important issue is whether Michael Brownlee, MD greater risk reduction of diabetic complications can be achieved Irl B. Hirsch, MD without further lowering of HbA . The study by Monnier and 1c colleagues in this issue of JAMA provides new data to help IABETES AFFECTS AN ESTIMATED 20.8 MILLION IN- address this issue. Over the past 35 years, several major mo- dividuals in the United States, 7% of the current lecular mechanisms have been implicated in glucose- population, and the lifetime risk of developing mediated vascular damage. Each of these mechanisms has been 1,2 Ddiabetes for those born in the year 2000 is 35%. studied independently of the others, with no apparent com- Many of these individuals will develop diabetes-specific mi- mon element linking them. Recent discoveries have made clear crovascular pathology in the retina, renal glomerulus, and that all of these seemingly unrelated mechanisms may arise peripheral nerve and accelerated atherosclerotic macrovas- from a single, hyperglycemia-induced process: the overpro- cular disease affecting arteries http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Glycemic Variability: A Hemoglobin A1c–Independent Risk Factor for Diabetic Complications

Brownlee, Michael; Hirsch, Irl B.
JAMA , Volume 295 (14) – Apr 12, 2006
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References (18)

Publisher
American Medical Association
Copyright
Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.295.14.1707
pmid
16609094
Publisher site
See Article on Publisher Site

Abstract

Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. Glycemic Variability: A Hemoglobin A – 1c Independent Risk Factor for Diabetic Complications Considering these facts, an important issue is whether Michael Brownlee, MD greater risk reduction of diabetic complications can be achieved Irl B. Hirsch, MD without further lowering of HbA . The study by Monnier and 1c colleagues in this issue of JAMA provides new data to help IABETES AFFECTS AN ESTIMATED 20.8 MILLION IN- address this issue. Over the past 35 years, several major mo- dividuals in the United States, 7% of the current lecular mechanisms have been implicated in glucose- population, and the lifetime risk of developing mediated vascular damage. Each of these mechanisms has been 1,2 Ddiabetes for those born in the year 2000 is 35%. studied independently of the others, with no apparent com- Many of these individuals will develop diabetes-specific mi- mon element linking them. Recent discoveries have made clear crovascular pathology in the retina, renal glomerulus, and that all of these seemingly unrelated mechanisms may arise peripheral nerve and accelerated atherosclerotic macrovas- from a single, hyperglycemia-induced process: the overpro- cular disease affecting arteries

Journal

JAMA – American Medical Association

Published: Apr 12, 2006

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