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Opinion EDITORIAL Prioritizing Dissemination and Implementation Science in Cardiometabolic Medicine CONNECTing the Dots Ankeet S. Bhatt, MD, MBA; Scott D. Solomon, MD; Muthiah Vaduganathan, MD, MPH charge plans that included rationale for prescribed medica- Heart failure with reduced ejection fraction serves as a pro- totypical example in which advances in scientific discovery tions and contingency plans. have not been fully realized in clinical practice. In recent years, The in-hospital and postdischarge intervention did not stepwise progress in discovery science has afforded the avail- result in improvement in clinical outcomes or measures of ability of several disease- quality of care, based on the coprimary outcomes of time to modifying therapies. Com- first heart failure rehospitalization or death or change in a Related article page 314 plete uptake of contemporary composite heart failure quality-of-care score (based on per- multidrug regimens is estimated to provide significant im- centage of recommendations followed). Specifically, heart provements in longevity and event-free survival. However, failure rehospitalization or all-cause mortality occurred in deep, pervasive gaps have remained in the optimal adoption 38.6% in the intervention group vs 39.2% in the usual care of these therapies. Similar implementation gaps exist group (adjusted hazard ratio, 0.92 [95% CI, 0.81
JAMA – American Medical Association
Published: Jul 27, 2021
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