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LW Andersen, MJ Holmberg, KM Berg, MW Donnino, A Granfeldt (2019)
In-hospital cardiac arrest: a review, 321
Kim (2021)
138JAMA, 325
Ingram (2013)
2534J Am Coll Cardiol, 61
F Kim, C Maynard, C Dezfulian (2021)
Effect of out-of-hospital sodium nitrite on survival to hospital admission after cardiac arrest: a randomized clinical trial, 325
TE Ingram, AG Fraser, RA Bleasdale (2013)
Low-dose sodium nitrite attenuates myocardial ischemia and vascular ischemia-reperfusion injury in human models, 61
Andersen (2019)
1200JAMA, 321
Letters through the PFO. The abnormal endocardium that was fre- COMMENT & RESPONSE quently detected in patients who had a stroke could be a fac- Effect of Sodium Nitrite on Survival of Cardiac Arrest tor contributing to in situ thrombus formation. Ultimately, the to Hospital Admission relationship between PFO in situ thrombus and ischemic stroke To the Editor In a recent JAMA study, administration of so- remains uncertain. dium nitrite did not significantly improve survival to hospi- Limitations of the study include the small number of tal admission after out-of-hospital cardiac arrest. This result patients and lack of follow-up of asymptomatic patients. is contrary to animal studies that have shown a protective ef- Additionally, the number and volume of in situ thrombi may fect of sodium nitrite in the process of ischemia and be underestimated due to the field of view of OCT. Further 2 1 reperfusion. In the study by Dr Kim and colleagues, sodium research is ongoing to investigate the microstructure of PFOs nitrite was administered in patients over a longer period than in a large population. in the animal studies, and that may have contributed to the Chaowu Yan, PhD, MD negative outcome. Hua Li, MD
JAMA – American Medical Association
Published: May 25, 2021
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