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Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy

Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy Key PointsQuestionWhat are the risks of primary hepatic malignancies or death by age 75 years in hemochromatosis HFE p.C282Y homozygotes identified in genotyping in a community sample? FindingsIn this cohort study that included 451 186 individuals, the risk of primary hepatic malignancy among 1294 male homozygous participants compared with men without pathogenic variants was 7.2% vs 0.6%, and the risk of all-cause death was 19.5% vs 15.1%; both differences were statistically significant. There were no statistically significant associations for women. MeaningAmong men, HFE p.C282Y homozygosity was significantly associated with increased risk for incident primary hepatic malignancy and excess mortality. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy

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References (28)

Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2020.21566
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat are the risks of primary hepatic malignancies or death by age 75 years in hemochromatosis HFE p.C282Y homozygotes identified in genotyping in a community sample? FindingsIn this cohort study that included 451 186 individuals, the risk of primary hepatic malignancy among 1294 male homozygous participants compared with men without pathogenic variants was 7.2% vs 0.6%, and the risk of all-cause death was 19.5% vs 15.1%; both differences were statistically significant. There were no statistically significant associations for women. MeaningAmong men, HFE p.C282Y homozygosity was significantly associated with increased risk for incident primary hepatic malignancy and excess mortality.

Journal

JAMAAmerican Medical Association

Published: Nov 24, 2020

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