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Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness Among Patients With Moderate or Severe Obstructive Sleep Apnea

Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and... Key PointsQuestionIs multilevel airway surgery effective in adults with moderate or severe obstructive sleep apnea (OSA) who cannot tolerate or adhere to device use? FindingsIn this randomized clinical trial of 102 adults, modified uvulopalatopharyngoplasty and radiofrequency in saline tongue reduction, compared with ongoing medical management, significantly improved the apnea-hypopnea index (mean baseline-adjusted between-group difference, −17.6 events per hour of sleep) and patient-reported sleepiness (mean baseline-adjusted between-group difference in Epworth Sleepiness Scale, −6.7; range, 0-24; higher score indicates greater sleepiness) at 6 months. MeaningIn this preliminary study of adults with moderate or severe OSA who failed conventional treatment, combined palatal and tongue surgery improved patient-reported sleepiness and polysomnographic measures of OSA severity at 6 months, although further research is needed to confirm these findings in additional populations and to evaluate the safety, clinical utility, and long-term efficacy of multilevel upper airway surgery for treatment of individuals with OSA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness Among Patients With Moderate or Severe Obstructive Sleep Apnea

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References (50)

Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2020.14265
Publisher site
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Abstract

Key PointsQuestionIs multilevel airway surgery effective in adults with moderate or severe obstructive sleep apnea (OSA) who cannot tolerate or adhere to device use? FindingsIn this randomized clinical trial of 102 adults, modified uvulopalatopharyngoplasty and radiofrequency in saline tongue reduction, compared with ongoing medical management, significantly improved the apnea-hypopnea index (mean baseline-adjusted between-group difference, −17.6 events per hour of sleep) and patient-reported sleepiness (mean baseline-adjusted between-group difference in Epworth Sleepiness Scale, −6.7; range, 0-24; higher score indicates greater sleepiness) at 6 months. MeaningIn this preliminary study of adults with moderate or severe OSA who failed conventional treatment, combined palatal and tongue surgery improved patient-reported sleepiness and polysomnographic measures of OSA severity at 6 months, although further research is needed to confirm these findings in additional populations and to evaluate the safety, clinical utility, and long-term efficacy of multilevel upper airway surgery for treatment of individuals with OSA.

Journal

JAMA – American Medical Association

Published: Sep 22, 2020

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