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References (44)
-
N. Devlin, K. Shah, Yan Feng, B. Mulhern, B. Hout (2017)
Valuing health‐related quality of life: An EQ‐5D‐5L value set for EnglandHealth Economics, 27
-
A. Rhodes, Laura Evans, W. Alhazzani, M. Levy, M. Antonelli, R. Ferrer, Anand Kumar, J. Sevransky, C. Sprung, M. Nunnally, B. Rochwerg, G. Rubenfeld, D. Angus, D. Annane, R. Beale, G. Bellinghan, G. Bernard, J. Chiche, C. Coopersmith, D. Backer, C. French, S. Fujishima, H. Gerlach, J. Hidalgo, S. Hollenberg, A. Jones, D. Karnad, R. Kleinpell, Y. Koh, T. Lisboa, F. Machado, J. Marini, J. Marshall, J. Mazuski, L. McIntyre, A. McLean, S. Mehta, R. Moreno, J. Myburgh, P. Navalesi, O. Nishida, T. Osborn, A. Perner, Colleen Plunkett, M. Ranieri, C. Schorr, Maureen Seckel, C. Seymour, L. Shieh, K. Shukri, S. Simpson, M. Singer, B. Thompson, S. Townsend, T. Poll, J. Vincent, W. Wiersinga, J. Zimmerman, R. Dellinger (2017)
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016Critical Care Medicine, 45
-
Charing Cross Hospital: (Laura Curran, BN; David Antcliffe, PhD -
Léa Lemasle, A. Blet, C. Geven, Ményssa Cherifa, B. Deniau, A. Hollinger, Marie-Céline Fournier, X. Monnet, I. Rennuit, M. Darmon, P. Laterre, J. Struck, O. Hartmann, A. Bergmann, A. Mebazaa, E. Gayat (2019)
Bioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study.Critical Care Medicine
-
F. Lamontagne, D. Cohen, M. Herridge (2017)
Understanding patient-centredness: contrasting expert versus patient perspectives on vasopressor therapy for shockIntensive Care Medicine, 43
-
Ashraf Roshdy, PhD; Ahmed Zaki, MD; Estefania Treus, BSc; Yvonna Marasigan, RN) -
BSn); Countess of Chester Hospital -
Arrowe Park Hospital (Nadine Weeks, BSc; Paul Jeanrenaud, MBChB -
Singer (2016)
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).JAMA, 315
-
R. Dellinger, M. Levy, A. Rhodes, D. Annane, H. Gerlach, S. Opal, J. Sevransky, C. Sprung, I. Douglas, R. Jaeschke, T. Osborn, M. Nunnally, S. Townsend, K. Reinhart, R. Kleinpell, D. Angus, C. Deutschman, F. Machado, G. Rubenfeld, S. Webb, R. Beale, J. Vincent, R. Moreno (2013)
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock 2012Critical Care Medicine, 41
-
I. White, P. Royston, A. Wood (2011)
Multiple imputation using chained equations: Issues and guidance for practiceStatistics in Medicine, 30
-
D. Rubin (1989)
Multiple imputation for nonresponse in surveys -
M. Herdman, C. Gudex, Andrew Lloyd, M. Janssen, Paul Kind, David Parkin, G. Bonsel, Xavier Badia (2011)
Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)Quality of Life Research, 20
-
D. Needham, Kristin Sepulveda, V. Dinglas, C. Chessare, L. Friedman, C. Bingham, A. Turnbull (2017)
Core Outcome Measures for Clinical Research in Acute Respiratory Failure Survivors. An International Modified Delphi Consensus StudyAmerican Journal of Respiratory and Critical Care Medicine, 196
-
Anthony Jorm (1994)
A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and cross-validationPsychological Medicine, 24
-
P. Ferrando-Vivas, Andrew Jones, K. Rowan, D. Harrison (2017)
Development and validation of the new ICNARC model for prediction of acute hospital mortality in adult critical careJournal of Critical Care, 38
-
K. Maheshwari, B. Nathanson, S. Munson, V. Khangulov, Mitali Stevens, Hussain Badani, A. Khanna, D. Sessler (2018)
The relationship between ICU hypotension and in-hospital mortality and morbidity in septic patientsIntensive Care Medicine, 44
-
R. Dellinger, M. Levy, A. Rhodes, D. Annane, H. Gerlach, S. Opal, J. Sevransky, C. Sprung, I. Douglas, R. Jaeschke, T. Osborn, M. Nunnally, S. Townsend, K. Reinhart, R. Kleinpell, D. Angus, C. Deutschman, F. Machado, G. Rubenfeld, S. Webb, R. Beale, J. Vincent, R. Moreno, The Subgroup (2013)
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012Intensive Care Medicine, 39
-
Hospital: (Aneta Bociek, BSc; Marlies Ostermann, PhD; Simon Sparkes, MBBS; Ruth Wan. MRes; and Andrea Kelly -
BSc); Princess Royal University Hospital, Farnborough -
Leicester Royal Infirmary: (Louise Houslip, MSc; Neil Flint, MBChB; Dawn Hales -
Altnagelvin Hospital: (Gail Quigley, PGDip; Noel Hemmings, FCARCSI -
M. Varpula, M. Tallgren, Katri Saukkonen, L. Voipio‐Pulkki, V. Pettilä (2005)
Hemodynamic variables related to outcome in septic shockIntensive Care Medicine, 31
-
A. Khanna, S. English, Xueyuan Wang, Kealy Ham, J. Tumlin, H. Szerlip, L. Busse, L. Altaweel, T. Albertson, C. Mackey, M. McCurdy, David Boldt, Stefan Chock, P. Young, K. Krell, R. Wunderink, M. Ostermann, R. Murugan, M. Gong, R. Panwar, J. Hästbacka, R. Favory, B. Venkatesh, B. Thompson, R. Bellomo, J. Jensen, J. Jensen, Stew Kroll, L. Chawla, G. Tidmarsh, G. Tidmarsh, G. Tidmarsh, A. Deane (2017)
Angiotensin II for the Treatment of Vasodilatory ShockThe New England Journal of Medicine, 377
-
P. Asfar, F. Meziani, J. Hamel, F. Grelon, B. Mégarbane, N. Anguel, J. Mira, P. Dequin, S. Gergaud, N. Weiss, F. Legay, Y. Tulzo, M. Conrad, R. Robert, F. Gonzalez, C. Guitton, F. Tamion, J. Tonnelier, P. Guezennec, T. Linden, A. Vieillard-Baron, E. Mariotte, Gael Pradel, O. Lesieur, J. Ricard, Fabien Hervé, D. Cheyron, C. Guérin, A. Mercat, J. Teboul, P. Radermacher (2014)
High versus low blood-pressure target in patients with septic shock.The New England journal of medicine, 370 17
-
Russells Hall Hospital: (Davinder Kaur, BSc; Mike Reay, MBBS; Vikram Anumakonda, MBBS; Rachel Collins, DipHE -
A. Rhodes, Laura Evans, W. Alhazzani, M. Levy, M. Antonelli, R. Ferrer, Anand Kumar, J. Sevransky, C. Sprung, M. Nunnally, B. Rochwerg, G. Rubenfeld, D. Angus, D. Annane, R. Beale, G. Bellinghan, G. Bernard, J. Chiche, C. Coopersmith, D. Backer, C. French, S. Fujishima, H. Gerlach, J. Hidalgo, S. Hollenberg, A. Jones, D. Karnad, R. Kleinpell, Younsuk Koh, T. Lisboa, F. Machado, J. Marini, J. Marshall, J. Mazuski, L. McIntyre, A. McLean, S. Mehta, R. Moreno, J. Myburgh, P. Navalesi, O. Nishida, T. Osborn, A. Perner, Colleen Plunkett, M. Ranieri, C. Schorr, Maureen Seckel, C. Seymour, L. Shieh, K. Shukri, S. Simpson, M. Singer, B. Thompson, S. Townsend, T. Poll, J. Vincent, W. Wiersinga, J. Zimmerman, R. Dellinger (2017)
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016Intensive Care Medicine, 43
-
Hospital: (Samantha Hendry, BSc; Ingeborg Welters, PhD -
F. Lamontagne, J. Marshall, N. Adhikari (2017)
Permissive hypotension during shock resuscitation: equipoise in all patients?Intensive Care Medicine, 44
-
Glangwili General Hospital: (Ulla Chappell, PhD: Igor Otahal -
Alvin Richards-Belle, P. Mouncey, Richard Grieve, David Harrison, M. Sadique, D. Henry, Chris Whitman, J. Camsooksai, A. Gordon, J Young, K. Rowan, F. Lamontagne (2019)
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trialJournal of the Intensive Care Society, 21
-
K. Thomas, Akshay Patel, M. Sadique, R. Grieve, A. Mason, Silvia Moler, A. Gordon, K. Rowan, P. Mouncey, F. Lamontagne, D. Harrison (2019)
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Statistical and Health Economic Analysis Plan for the 65 trialJournal of the Intensive Care Society
-
F. Lamontagne, A. Day, M. Meade, D. Cook, G. Guyatt, M. Hylands, P. Radermacher, J. Chrétien, Nicolas Beaudoin, P. Hebert, F. D’Aragon, F. Meziani, P. Asfar (2017)
Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shockIntensive Care Medicine, 44
-
F. Lamontagne, M. Meade, P. Hebert, P. Asfar, F. Lauzier, A. Seely, A. Day, S. Mehta, J. Muscedere, S. Bagshaw, N. Ferguson, D. Cook, S. Kanji, A. Turgeon, M. Herridge, S. Subramanian, J. Lacroix, N. Adhikari, D. Scales, A. Fox-Robichaud, Y. Skrobik, R. Whitlock, R. Green, Karen Koo, T. Tanguay, S. Magder, D. Heyland, for Group (2016)
Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trialIntensive Care Medicine, 42
-
Broomfield Hospital: (Rebecca Keskeys, BSc; Jayachandran Radhakrishnan, DipHE; Fiona McNeela, BSc -
D. Harrison, G. Parry, J. Carpenter, A. Short, K. Rowan (2007)
A new risk prediction model for critical care: The Intensive Care National Audit & Research Centre (ICNARC) model*Critical Care Medicine, 35
-
E. Milner (1897)
SALFORD ROYAL HOSPITAL.The Lancet, 150
-
F. Lamontagne, D. Cook, M. Meade, A. Seely, A. Day, E. Charbonney, K. Serri, Y. Skrobik, P. Hebert, C. St-Arnaud, H. Quiroz-Martinez, M. Mayette, D. Heyland (2017)
Vasopressor Use for Severe Hypotension—A Multicentre Prospective Observational StudyPLoS ONE, 12
-
E. Vail, H. Gershengorn, M. Hua, A. Walkey, H. Wunsch (2016)
Epidemiology of Vasopressin Use for Adults with Septic Shock.Annals of the American Thoracic Society, 13 10
-
W. Knaus, E. Draper, D. Wagner, J. Zimmerman (1985)
APACHE II: a severity of disease classification system.Critical Care Medicine, 13
-
C. St-Arnaud, J. Éthier, C. Hamielec, A. Bersten, G. Guyatt, M. Meade, Qi Zhou, Marc-André Leclair, Alpesh Patel, F. Lamontagne (2013)
Prescribed targets for titration of vasopressors in septic shock: a retrospective cohort study.CMAJ open, 1 4
-
D. Hemmy (2018)
Angiotensin II for the Treatment of Vasodilatory ShockJournal of Emergency Medicine, 54
-
M. Shankar-Hari, Gary Phillips, M. Levy, C. Seymour, Vincent Liu, C. Deutschman, D. Angus, G. Rubenfeld, M. Singer (2016)
Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).JAMA, 315 8
-
University Hospital Coventry
- Publisher
- American Medical Association
- Copyright
- Copyright 2020 American Medical Association. All Rights Reserved.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.2020.0930
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionWhat is the effect on mortality at 90 days of reducing the exposure to vasopressors through permissive hypotension (mean arterial pressure target of 60-65 mm Hg) in intensive care unit (ICU) patients aged 65 years or older receiving vasopressors for vasodilatory hypotension? FindingsIn this randomized clinical trial that included 2600 patients aged 65 years or older with vasodilatory hypotension, treatment with permissive hypotension resulted in death at 90 days among 41.0% of patients compared with 43.8% of those receiving usual care, a difference that was not statistically significant. MeaningReducing the exposure to vasopressors through permissive hypotension did not significantly reduce mortality at 90 days.
Journal
JAMA – American Medical Association
Published: Mar 10, 2020