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- Publisher
- American Medical Association
- Copyright
- Copyright 2018 American Medical Association. All Rights Reserved.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.2018.0949
- pmid
- 29486489
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionIn ICU patients receiving invasive ventilation, is a strategy using on-demand nebulization of acetylcysteine or salbutamol inferior to using routine nebulization of acetylcysteine with salbutamol with respect to days ventilator-free and alive at day 28? FindingsIn this randomized clinical trial that included 922 ICU patients receiving invasive ventilation who were expected to not be extubated within 24 hours, on-demand compared with routine nebulization of acetylcysteine with salbutamol resulted in 20 vs 21 days ventilator-free and alive at day 28, a difference that met the noninferiority margin of −0.5 days. MeaningAmong ICU patients receiving invasive ventilation, on-demand nebulization was not inferior to routine nebulization of acetylcysteine with salbutamol.
Journal
JAMA – American Medical Association
Published: Mar 13, 2018