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Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction

Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and... Key PointsQuestionDoes therapy with the glucagon-like peptide 1 agonist liraglutide improve clinical stability in patients with advanced heart failure? FindingsIn this randomized clinical trial of 300 adults with advanced heart failure, liraglutide had no significant effect on posthospitalization clinical stability based on a global rank score of time to death, time to rehospitalization for heart failure, and time-averaged proportional change in N-terminal pro-B-type natriuretic peptide level. There was no benefit observed among the 178 patients with type 2 diabetes. MeaningThese findings do not support the use of liraglutide for improving clinical stability in patients with advanced heart failure and reduced left ventricular ejection fraction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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References (22)

Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2016.10260
pmid
27483064
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDoes therapy with the glucagon-like peptide 1 agonist liraglutide improve clinical stability in patients with advanced heart failure? FindingsIn this randomized clinical trial of 300 adults with advanced heart failure, liraglutide had no significant effect on posthospitalization clinical stability based on a global rank score of time to death, time to rehospitalization for heart failure, and time-averaged proportional change in N-terminal pro-B-type natriuretic peptide level. There was no benefit observed among the 178 patients with type 2 diabetes. MeaningThese findings do not support the use of liraglutide for improving clinical stability in patients with advanced heart failure and reduced left ventricular ejection fraction.

Journal

JAMAAmerican Medical Association

Published: Aug 2, 2016

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