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Personalized Medicine vs Guideline-Based Medicine

Personalized Medicine vs Guideline-Based Medicine VIEWPOINT ONLINE FIRST Personalized Medicine vs Guideline-Based Medicine guidelines are applied in clinical practice differ in certain criti- Jeffrey J. Goldberger, MD, MBA cal characteristics from those of the trial population on which Alfred E. Buxton, MD the guideline recommendation is based. That is, the general- izabilityoftrialresultstoclinicalpracticemaybecompromised WO PHILOSOPHICAL APPROACHES TO THE IMPLEMEN- by a number of factors involved in execution of the trial, such tation of optimal health care are emerging—the use as where patients were recruited (eg, inpatient vs outpatient of evidence-based guidelines and the application of venue, tertiary referral centers vs primary care centers). Tpersonalized (or “precision”) medicine. Even though The President’s Council of Advisors on Science and Tech- both approaches have important merits, they both also can nology noted that personalized medicine “refers to the tai- present conflicting priorities that must be reconciled be- loring of medical treatment to the individual characteris- fore they can be best leveraged. tics of each patient. It does not literally mean the creation Evidence-based guidelines are generated based on the body of drugs or medical devices that are unique to a patient, but of clinical data available for a particular question. The highest rather the ability to classify individuals http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Personalized Medicine vs Guideline-Based Medicine

Goldberger, Jeffrey J.; Buxton, Alfred E.
JAMA , Volume 309 (24) – Jun 26, 2013
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References (11)

Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2013.6629
pmid
23712449
Publisher site
See Article on Publisher Site

Abstract

VIEWPOINT ONLINE FIRST Personalized Medicine vs Guideline-Based Medicine guidelines are applied in clinical practice differ in certain criti- Jeffrey J. Goldberger, MD, MBA cal characteristics from those of the trial population on which Alfred E. Buxton, MD the guideline recommendation is based. That is, the general- izabilityoftrialresultstoclinicalpracticemaybecompromised WO PHILOSOPHICAL APPROACHES TO THE IMPLEMEN- by a number of factors involved in execution of the trial, such tation of optimal health care are emerging—the use as where patients were recruited (eg, inpatient vs outpatient of evidence-based guidelines and the application of venue, tertiary referral centers vs primary care centers). Tpersonalized (or “precision”) medicine. Even though The President’s Council of Advisors on Science and Tech- both approaches have important merits, they both also can nology noted that personalized medicine “refers to the tai- present conflicting priorities that must be reconciled be- loring of medical treatment to the individual characteris- fore they can be best leveraged. tics of each patient. It does not literally mean the creation Evidence-based guidelines are generated based on the body of drugs or medical devices that are unique to a patient, but of clinical data available for a particular question. The highest rather the ability to classify individuals

Journal

JAMA – American Medical Association

Published: Jun 26, 2013

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