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(2013)
re-tracted in: Lancet . 2004;363(9411):750]
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Concerns about reliability in the Trial to Assess Chelation Therapy (TACT).JAMA, 309 12
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Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. Evaluation of the Trial to Assess Chelation Therapy (TACT) The Scientific Process, Peer Review, and Editorial Scrutiny sample size and alteration of the prespecified statistical sig- Howard Bauchner, MD nificance levels because of multiple interim analyses. Phil B. Fontanarosa, MD, MBA In light of these and other concerns, the editorial assess- Robert M. Golub, MD ment of TACT, like other studies with complex interre- lated issues, was extensive and comprehensive because the N THIS ISSUE OF JAMA,LAMAS AND COLLEAGUES evaluation extends beyond assessment of scientific validity report the results of the Trial to Assess Chelation and clinical relevance. Accordingly, the editorial review and Therapy (TACT). In this multicenter clinical trial, scientific assessment involved not only JAMA’s usual level I1708 patients with previous myocardial infarction of scrutiny and diligence in evaluating the research report, (MI) were randomized to receive 40 infusions of chela- including careful review of the study protocols, statistical tion solution vs placebo. After a median follow-up of 55 analysis plans, and methods papers—it also involved as- months, the primary end point (a composite of total mor- sessment of OHRP
JAMA – American Medical Association
Published: Mar 27, 2013
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