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Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy

Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy ORIGINAL CONTRIBUTION Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy A Randomized Trial Jerome Engel Jr, MD, PhD Context Despite reported success, surgery for pharmacoresistant seizures is often Michael P. McDermott, PhD seen as a last resort. Patients are typically referred for surgery after 20 years of sei- zures, often too late to avoid significant disability and premature death. Samuel Wiebe, MD Objective We sought to determine whether surgery soon after failure of 2 antiepi- John T. Langfitt, PhD leptic drug (AED) trials is superior to continued medical management in controlling John M. Stern, MD seizures and improving quality of life (QOL). Sandra Dewar, RN Design,Setting,andParticipants The Early Randomized Surgical Epilepsy Trial (ERSET) is a multicenter, controlled, parallel-group clinical trial performed at 16 US epilepsy sur- Michael R. Sperling, MD gery centers. The 38 participants (18 men and 20 women; aged 12 years) had mesial Irenita Gardiner, RN temporal lobe epilepsy (MTLE) and disabling seizues for no more than 2 consecutive years Giuseppe Erba, MD following adequate trials of 2 brand-name AEDs. Eligibility for anteromesial temporal resec- tion (AMTR) was based on a standardized presurgical evaluation protocol. Participants Itzhak Fried, MD, PhD were randomized to continued AED treatment or http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy

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References (55)

Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2012.220
pmid
22396514
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy A Randomized Trial Jerome Engel Jr, MD, PhD Context Despite reported success, surgery for pharmacoresistant seizures is often Michael P. McDermott, PhD seen as a last resort. Patients are typically referred for surgery after 20 years of sei- zures, often too late to avoid significant disability and premature death. Samuel Wiebe, MD Objective We sought to determine whether surgery soon after failure of 2 antiepi- John T. Langfitt, PhD leptic drug (AED) trials is superior to continued medical management in controlling John M. Stern, MD seizures and improving quality of life (QOL). Sandra Dewar, RN Design,Setting,andParticipants The Early Randomized Surgical Epilepsy Trial (ERSET) is a multicenter, controlled, parallel-group clinical trial performed at 16 US epilepsy sur- Michael R. Sperling, MD gery centers. The 38 participants (18 men and 20 women; aged 12 years) had mesial Irenita Gardiner, RN temporal lobe epilepsy (MTLE) and disabling seizues for no more than 2 consecutive years Giuseppe Erba, MD following adequate trials of 2 brand-name AEDs. Eligibility for anteromesial temporal resec- tion (AMTR) was based on a standardized presurgical evaluation protocol. Participants Itzhak Fried, MD, PhD were randomized to continued AED treatment or

Journal

JAMA – American Medical Association

Published: Mar 7, 2012

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