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Genetic Variants and Associations of 25-Hydroxyvitamin D Concentrations With Major Clinical Outcomes

Genetic Variants and Associations of 25-Hydroxyvitamin D Concentrations With Major Clinical Outcomes ORIGINAL CONTRIBUTION Genetic Variants and Associations of 25-Hydroxyvitamin D Concentrations With Major Clinical Outcomes Gregory P. Levin, PhD Context Lower serum 25-hydroxyvitamin D concentrations are associated with greater Cassianne Robinson-Cohen, PhD risks of many chronic diseases across large, prospective community-based studies. Sub- strate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full Ian H. de Boer, MD, MS biological activity, and complex metabolic pathways suggest that interindividual vari- Denise K. Houston, PhD ability in vitamin D metabolism may alter the clinical consequences of measured se- rum 25-hydroxyvitamin D. Kurt Lohman, MS Objective To investigate whether common variation within genes encoding the vi- Yongmei Liu, PhD tamin D–binding protein, megalin, cubilin, CYP27B1, CYP24A1, and the vitamin D Stephen B. Kritchevsky, PhD receptor (VDR) modify associations of low 25-hydroxyvitamin D with major clinical Jane A. Cauley, DrPh outcomes. Toshiko Tanaka, PhD Design, Setting, and Participants Examination of 141 single-nucleotide poly- morphisms in a discovery cohort of 1514 white participants (who were recruited Luigi Ferrucci, MD, PhD from 4 US regions) from the community-based Cardiovascular Health Study. Par- Stefania Bandinelli, MD ticipants had serum 25-hydroxyvitamin D measurements in 1992-1993 and were followed up for a median of 11 years (through 2006). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Genetic Variants and Associations of 25-Hydroxyvitamin D Concentrations With Major Clinical Outcomes

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References (47)

Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2012.17304
pmid
23150009
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Genetic Variants and Associations of 25-Hydroxyvitamin D Concentrations With Major Clinical Outcomes Gregory P. Levin, PhD Context Lower serum 25-hydroxyvitamin D concentrations are associated with greater Cassianne Robinson-Cohen, PhD risks of many chronic diseases across large, prospective community-based studies. Sub- strate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full Ian H. de Boer, MD, MS biological activity, and complex metabolic pathways suggest that interindividual vari- Denise K. Houston, PhD ability in vitamin D metabolism may alter the clinical consequences of measured se- rum 25-hydroxyvitamin D. Kurt Lohman, MS Objective To investigate whether common variation within genes encoding the vi- Yongmei Liu, PhD tamin D–binding protein, megalin, cubilin, CYP27B1, CYP24A1, and the vitamin D Stephen B. Kritchevsky, PhD receptor (VDR) modify associations of low 25-hydroxyvitamin D with major clinical Jane A. Cauley, DrPh outcomes. Toshiko Tanaka, PhD Design, Setting, and Participants Examination of 141 single-nucleotide poly- morphisms in a discovery cohort of 1514 white participants (who were recruited Luigi Ferrucci, MD, PhD from 4 US regions) from the community-based Cardiovascular Health Study. Par- Stefania Bandinelli, MD ticipants had serum 25-hydroxyvitamin D measurements in 1992-1993 and were followed up for a median of 11 years (through 2006).

Journal

JAMA – American Medical Association

Published: Nov 14, 2012

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