This Week in JAMA
Abstract
Prenatal Exposure to Valproate and Risk of Autism Animal studies and several patient case series have suggested a possible association between in utero exposure to the antiepileptic drug valproate and autism. In a population-based study of 655 615 Danish children born from 1996 to 2006 and followed up for a mean 8.8 years (range, 4-14 years), Christensen and colleagues examined whether prenatal exposure to valproate was associated with an increased risk of autism spectrum disorders. The...