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Fatal and Nonfatal Outcomes, Incidence of Hypertension, and Blood Pressure Changes in Relation to Urinary Sodium Excretion

Fatal and Nonfatal Outcomes, Incidence of Hypertension, and Blood Pressure Changes in Relation to... ORIGINAL CONTRIBUTION Fatal and Nonfatal Outcomes, Incidence of Hypertension, and Blood Pressure Changes in Relation to Urinary Sodium Excretion Katarzyna Stolarz-Skrzypek, MD, Context Extrapolations from observational studies and short-term intervention trials sug- PhD gest that population-wide moderation of salt intake might reduce cardiovascular events. Tatiana Kuznetsova, MD, PhD Objective To assess whether 24-hour urinary sodium excretion predicts blood pres- Lutgarde Thijs, MSc sure (BP) and health outcomes. Vale´rie Tikhonoff, MD, PhD Design, Setting, and Participants Prospective population study, involving 3681 participants without cardiovascular disease (CVD) who are members of families that were Jitka Seidlerova´, MD, PhD randomly enrolled in the Flemish Study on Genes, Environment, and Health Outcomes Tom Richart, MD (1985-2004) or in the European Project on Genes in Hypertension (1999-2001). Of 3681 participants without CVD, 2096 were normotensive at baseline and 1499 had BP and Yu Jin, MD sodium excretion measured at baseline and last follow-up (2005-2008). Agnieszka Olszanecka, MD, PhD Main Outcome Measures Incidence of mortality and morbidity and association Sofia Malyutina, MD, PhD between changes in BP and sodium excretion. Multivariable-adjusted hazard ratios (HRs) express the risk in tertiles of sodium excretion relative to average risk in the whole Edoardo Casiglia, MD, PhD study population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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References (49)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2011.574
pmid
21540421
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Fatal and Nonfatal Outcomes, Incidence of Hypertension, and Blood Pressure Changes in Relation to Urinary Sodium Excretion Katarzyna Stolarz-Skrzypek, MD, Context Extrapolations from observational studies and short-term intervention trials sug- PhD gest that population-wide moderation of salt intake might reduce cardiovascular events. Tatiana Kuznetsova, MD, PhD Objective To assess whether 24-hour urinary sodium excretion predicts blood pres- Lutgarde Thijs, MSc sure (BP) and health outcomes. Vale´rie Tikhonoff, MD, PhD Design, Setting, and Participants Prospective population study, involving 3681 participants without cardiovascular disease (CVD) who are members of families that were Jitka Seidlerova´, MD, PhD randomly enrolled in the Flemish Study on Genes, Environment, and Health Outcomes Tom Richart, MD (1985-2004) or in the European Project on Genes in Hypertension (1999-2001). Of 3681 participants without CVD, 2096 were normotensive at baseline and 1499 had BP and Yu Jin, MD sodium excretion measured at baseline and last follow-up (2005-2008). Agnieszka Olszanecka, MD, PhD Main Outcome Measures Incidence of mortality and morbidity and association Sofia Malyutina, MD, PhD between changes in BP and sodium excretion. Multivariable-adjusted hazard ratios (HRs) express the risk in tertiles of sodium excretion relative to average risk in the whole Edoardo Casiglia, MD, PhD study population.

Journal

JAMAAmerican Medical Association

Published: May 4, 2011

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