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ORIGINAL CONTRIBUTION Fatal and Nonfatal Outcomes, Incidence of Hypertension, and Blood Pressure Changes in Relation to Urinary Sodium Excretion Katarzyna Stolarz-Skrzypek, MD, Context Extrapolations from observational studies and short-term intervention trials sug- PhD gest that population-wide moderation of salt intake might reduce cardiovascular events. Tatiana Kuznetsova, MD, PhD Objective To assess whether 24-hour urinary sodium excretion predicts blood pres- Lutgarde Thijs, MSc sure (BP) and health outcomes. Vale´rie Tikhonoff, MD, PhD Design, Setting, and Participants Prospective population study, involving 3681 participants without cardiovascular disease (CVD) who are members of families that were Jitka Seidlerova´, MD, PhD randomly enrolled in the Flemish Study on Genes, Environment, and Health Outcomes Tom Richart, MD (1985-2004) or in the European Project on Genes in Hypertension (1999-2001). Of 3681 participants without CVD, 2096 were normotensive at baseline and 1499 had BP and Yu Jin, MD sodium excretion measured at baseline and last follow-up (2005-2008). Agnieszka Olszanecka, MD, PhD Main Outcome Measures Incidence of mortality and morbidity and association Sofia Malyutina, MD, PhD between changes in BP and sodium excretion. Multivariable-adjusted hazard ratios (HRs) express the risk in tertiles of sodium excretion relative to average risk in the whole Edoardo Casiglia, MD, PhD study population.
JAMA – American Medical Association
Published: May 4, 2011
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