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ORIGINAL CONTRIBUTION Cancer Risk Among Patients With Myotonic Muscular Dystrophy Shahinaz M. Gadalla, MD, PhD Context Myotonic muscular dystrophy (MMD) is an autosomal-dominant multisys- tem neuromuscular disorder characterized by unstable nucleotide repeat expansions. Marie Lund, MD Case reports have suggested that MMD patients may be at increased risk of malig- Ruth M. Pfeiffer, PhD nancy, putative risks that have never been quantified. Sanne Gørtz, MSc Objective To quantitatively evaluate cancer risk in patients with MMD, overall and Christine M. Mueller, DO by sex and age. Richard T. Moxley III, MD Design, Setting, and Participants We identified 1658 patients with an MMD dis- charge diagnosis in the Swedish Hospital Discharge Register or Danish National Pa- Sigurdur Y. Kristinsson, MD, PhD tient Registry between 1977 and 2008. We linked these patients to their correspond- Magnus Bjo¨rkholm, MD, PhD ing cancer registry. Patients were followed up from date of first MMD-related inpatient or outpatient contact to first cancer diagnosis, death, emigration, or completion of can- Fatma M. Shebl, MD, PhD cer registration. James E. Hilbert, MS Main Outcome Measures Risks of all cancers combined and by anatomic site, strati- Ola Landgren, MD, PhD fied by sex and age. Jan Wohlfahrt, DMSc Results
JAMA – American Medical Association
Published: Dec 14, 2011
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