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Cancer Risk Among Patients With Myotonic Muscular Dystrophy

Cancer Risk Among Patients With Myotonic Muscular Dystrophy ORIGINAL CONTRIBUTION Cancer Risk Among Patients With Myotonic Muscular Dystrophy Shahinaz M. Gadalla, MD, PhD Context Myotonic muscular dystrophy (MMD) is an autosomal-dominant multisys- tem neuromuscular disorder characterized by unstable nucleotide repeat expansions. Marie Lund, MD Case reports have suggested that MMD patients may be at increased risk of malig- Ruth M. Pfeiffer, PhD nancy, putative risks that have never been quantified. Sanne Gørtz, MSc Objective To quantitatively evaluate cancer risk in patients with MMD, overall and Christine M. Mueller, DO by sex and age. Richard T. Moxley III, MD Design, Setting, and Participants We identified 1658 patients with an MMD dis- charge diagnosis in the Swedish Hospital Discharge Register or Danish National Pa- Sigurdur Y. Kristinsson, MD, PhD tient Registry between 1977 and 2008. We linked these patients to their correspond- Magnus Bjo¨rkholm, MD, PhD ing cancer registry. Patients were followed up from date of first MMD-related inpatient or outpatient contact to first cancer diagnosis, death, emigration, or completion of can- Fatma M. Shebl, MD, PhD cer registration. James E. Hilbert, MS Main Outcome Measures Risks of all cancers combined and by anatomic site, strati- Ola Landgren, MD, PhD fied by sex and age. Jan Wohlfahrt, DMSc Results http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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References (46)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2011.1796
pmid
22166607
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Cancer Risk Among Patients With Myotonic Muscular Dystrophy Shahinaz M. Gadalla, MD, PhD Context Myotonic muscular dystrophy (MMD) is an autosomal-dominant multisys- tem neuromuscular disorder characterized by unstable nucleotide repeat expansions. Marie Lund, MD Case reports have suggested that MMD patients may be at increased risk of malig- Ruth M. Pfeiffer, PhD nancy, putative risks that have never been quantified. Sanne Gørtz, MSc Objective To quantitatively evaluate cancer risk in patients with MMD, overall and Christine M. Mueller, DO by sex and age. Richard T. Moxley III, MD Design, Setting, and Participants We identified 1658 patients with an MMD dis- charge diagnosis in the Swedish Hospital Discharge Register or Danish National Pa- Sigurdur Y. Kristinsson, MD, PhD tient Registry between 1977 and 2008. We linked these patients to their correspond- Magnus Bjo¨rkholm, MD, PhD ing cancer registry. Patients were followed up from date of first MMD-related inpatient or outpatient contact to first cancer diagnosis, death, emigration, or completion of can- Fatma M. Shebl, MD, PhD cer registration. James E. Hilbert, MS Main Outcome Measures Risks of all cancers combined and by anatomic site, strati- Ola Landgren, MD, PhD fied by sex and age. Jan Wohlfahrt, DMSc Results

Journal

JAMAAmerican Medical Association

Published: Dec 14, 2011

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