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ORIGINAL CONTRIBUTION Genetic Variants Associated With Cardiac Structure and Function A Meta-analysis and Replication of Genome-wide Association Data Ramachandran S. Vasan, MD; Nicole L. Context Echocardiographic measures of left ventricular (LV) structure and function Glazer, PhD; Janine F. Felix, MD, PhD; are heritable phenotypes of cardiovascular disease. Wolfgang Lieb, MD; Philipp S. Wild, MD; Objective To identify common genetic variants associated with cardiac structure and Stephan B. Felix, MD; Norbert Watzinger, function by conducting a meta-analysis of genome-wide association data in 5 population- MD; Martin G. Larson, ScD; Nicholas L. based cohort studies (stage 1) with replication (stage 2) in 2 other community-based samples. Smith, PhD; Abbas Dehghan, MD, DSc; Design, Setting, and Participants Within each of 5 community-based cohorts Anika Großhennig, PhD; Arne Schillert, comprising the EchoGen consortium (stage 1; n = 12 612 individuals of European an- PhD; Alexander Teumer, Dipl-Math; cestry; 55% women, aged 26-95 years; examinations between 1978-2008), we es- Reinhold Schmidt, MD; Sekar Kathiresan, timated the association between approximately 2.5 million single-nucleotide polymor- MD; Thomas Lumley, PhD; Yurii S. phisms (SNPs; imputed to the HapMap CEU panel) and echocardiographic traits. In Aulchenko, PhD; Inke R. König, PhD; stage 2, SNPs significantly associated with traits
JAMA – American Medical Association
Published: Jul 8, 2009
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