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QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies
- Publisher
- American Medical Association
- Copyright
- Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- DOI
- 10.1001/jama.2009.954
- pmid
- 19567438
- Publisher site
- See Article on Publisher Site
Abstract
ORIGINAL CONTRIBUTION Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease Paul Elliott, FRCP Context Plasma levels of C-reactive protein (CRP) are independently associated with John C. Chambers, PhD risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain. Weihua Zhang, PhD Objective To investigate association of genetic loci with CRP levels and risk of coro- Robert Clarke, MD nary heart disease. Jemma C. Hopewell, PhD Design, Setting, and Participants We first carried out a genome-wide associa- John F. Peden, PhD tion (n = 17 967) and replication study (n = 13 615) to identify genetic loci associated with plasma CRP concentrations. Data collection took place between 1989 and 2008 Jeanette Erdmann, PhD and genotyping between 2003 and 2008. We carried out a mendelian randomization Peter Braund, MSc study of the most closely associated single-nucleotide polymorphism (SNP) in the CRP locus and published data on other CRP variants involving a total of 28 112 cases and James C. Engert, PhD 100 823 controls, to investigate the association of CRP variants with coronary heart Derrick Bennett, PhD disease. We compared our finding
Journal
JAMA – American Medical Association
Published: Jul 1, 2009